ID G3WBI1_SARHA Unreviewed; 835 AA.
AC G3WBI1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Actin binding LIM protein 1 {ECO:0000313|Ensembl:ENSSHAP00000012786.2};
GN Name=ABLIM1 {ECO:0000313|Ensembl:ENSSHAP00000012786.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012786.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012786.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012786.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; G3WBI1; -.
DR STRING; 9305.ENSSHAP00000012786; -.
DR Ensembl; ENSSHAT00000012891.2; ENSSHAP00000012786.2; ENSSHAG00000025566.1.
DR eggNOG; KOG1044; Eukaryota.
DR GeneTree; ENSGT00950000182850; -.
DR InParanoid; G3WBI1; -.
DR TreeFam; TF318042; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0001725; C:stress fiber; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR CDD; cd09327; LIM1_abLIM; 1.
DR CDD; cd09328; LIM2_abLIM; 1.
DR CDD; cd09329; LIM3_abLIM; 1.
DR CDD; cd09330; LIM4_abLIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 4.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR032402; AbLIM_anchor.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24213; ACTIN-BINDING LIM PROTEIN; 1.
DR PANTHER; PTHR24213:SF18; ACTIN-BINDING LIM PROTEIN 1; 1.
DR Pfam; PF16182; AbLIM_anchor; 1.
DR Pfam; PF00412; LIM; 4.
DR Pfam; PF02209; VHP; 1.
DR SMART; SM00132; LIM; 4.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 99..158
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 159..218
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 226..285
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 767..835
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
FT REGION 361..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 94421 MW; 68AA17AF66635CD7 CRC64;
MPSFPPLKCL RKLCGLGKSK NLSSDRANFR DSFRRRSRLV IEDKNITGVP CPSPRRATIT
HLLYLQPEDY CLCAQLFNNF NTLVAHPQDP HHPSEKPVIQ CYKCGEPCKG EVLRVQTRHF
HIKCFTCKVC GCDLAQGGFF IKNGEYLCTL DYQRMYGTRC NGCGEFVEGE VVTALGKTYH
PNCFACTICK RPFPPGDRVT FNGRDCLCQL CAQPMSSSHK EVSSSSNCAG CGRDIKNGQA
LLALDKQWHL GCFKCKSCGK VLTGEYISKD GAPYCEKDYQ GLFGVKCESC QQFITGKVLE
AGDKHYHPSC ARCSRCNQMF TEGEEMYLQG STVWHPDCKQ STKTEEKLRL LPSPCLVNFN
KNQRQPTRTS SESIYSRPGS SIPGSPGHTI YAKVDNEILD YKDLAAIPKV KAIYDIERPD
LITYEPFYSS GYEDKQERQS LGESPRTLSP TPSAEGYQDV RDRMIHRSTS QGSINSPVYS
RHSYTPTTSR SPQHFHRPEL LSPGVQRLSH LRTSSLSSTH NDTRPNSPFR HHFFPHIKGN
EPSSGRNSPL PYRPDSRPLT PTYAQAPKHF HVPDQGINIY RKPPIYKQHA ALAAQSKSSE
DIIKSSKFPA AHAPDPNEIP KIETDHWPGP PSLAAVGTDM RRRSSGREED EEELQRRRQL
QEEQLLKLNS GLGQLILKEE MEKETRERTS LSASRYDSPL NSSLHTSSKT SSLPGYGKNG
LHRPVSTDFA QYNSYGDVSG GVRDFQTLPD GHVPGMRMDR GVSMPNMLEP KIFPYEMLMV
TNRGRNKILR DVDRTRLERH LAPEVFREIF GMSIQEFDKL PLWRRNDMKK KAKLF
//
