ID G3WBN8_SARHA Unreviewed; 385 AA.
AC G3WBN8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Metaxin 3 {ECO:0000313|Ensembl:ENSSHAP00000012843.1};
GN Name=MTX3 {ECO:0000313|Ensembl:ENSSHAP00000012843.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000012843.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000012843.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000012843.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004294}.
CC -!- SIMILARITY: Belongs to the metaxin family.
CC {ECO:0000256|ARBA:ARBA00009170}.
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DR RefSeq; XP_003759464.2; XM_003759416.2.
DR AlphaFoldDB; G3WBN8; -.
DR STRING; 9305.ENSSHAP00000012843; -.
DR Ensembl; ENSSHAT00000012948.2; ENSSHAP00000012843.1; ENSSHAG00000010987.2.
DR GeneID; 100927134; -.
DR KEGG; shr:100927134; -.
DR CTD; 345778; -.
DR eggNOG; KOG3028; Eukaryota.
DR GeneTree; ENSGT00950000182919; -.
DR HOGENOM; CLU_044137_5_1_1; -.
DR InParanoid; G3WBN8; -.
DR OMA; ANYFFGN; -.
DR OrthoDB; 2897805at2759; -.
DR TreeFam; TF313422; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0001401; C:SAM complex; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd03212; GST_C_Metaxin1_3; 1.
DR CDD; cd03078; GST_N_Metaxin1_like; 1.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR033468; Metaxin_GST.
DR InterPro; IPR019564; Sam37/metaxin_N.
DR PANTHER; PTHR12289; METAXIN RELATED; 1.
DR PANTHER; PTHR12289:SF30; METAXIN-3; 1.
DR Pfam; PF17171; GST_C_6; 1.
DR Pfam; PF10568; Tom37; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG01180; SUF1; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 96..215
FT /note="Mitochondrial outer membrane transport complex
FT Sam37/metaxin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10568"
FT DOMAIN 246..309
FT /note="Metaxin glutathione S-transferase"
FT /evidence="ECO:0000259|Pfam:PF17171"
FT REGION 351..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 43037 MW; 832F0BA9664B8718 CRC64;
MADKSFVGGI REPRQGLVRV IRRGRSGWGG GRVALERSEV SPKLAPHFGF RLSEAERRGG
GHFRGTRGRG GGKMAAPLEL RCWGGGWGLP SVHSESLVVL AYAKFSGAPL KVSVIDNTWR
GSRGDVPILT SEDNIVSQPA KILNFLRKQK YNADYQLSAK QGADTLAYIA LLEEKLLPAV
LHTFWIENDN YFTVTKPWFA SRIPFPLSLI LPGRMSKRAL NRILLTKGEP PHYHLKEVEA
QIYRDAKECL NLLSNRLGTS QFFFGNTPTT LDAYVFGFVA PLYKVHFPKV QLQEHVKQLS
NLCRFCDDIL SCYFRISLAG FSPAGQDTVD ANLQKLTQLV NKESNLIEKM DDNLRQSPQL
PPRKLPTLKL TTADEESNSF QPLSP
//
