ID G3WD46_SARHA Unreviewed; 922 AA.
AC G3WD46;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=BicC family RNA binding protein 1 {ECO:0000313|Ensembl:ENSSHAP00000013351.2};
GN Name=BICC1 {ECO:0000313|Ensembl:ENSSHAP00000013351.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013351.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000013351.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000013351.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
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DR AlphaFoldDB; G3WD46; -.
DR Ensembl; ENSSHAT00000013462.2; ENSSHAP00000013351.2; ENSSHAG00000011416.2.
DR GeneTree; ENSGT00940000156276; -.
DR HOGENOM; CLU_008040_0_0_1; -.
DR InParanoid; G3WD46; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd22422; KH-I_BICC1_rpt3; 1.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 3.30.310.270; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR047553; BICC1_KH-I_rpt3.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR10627:SF78; PROTEIN BICAUDAL C HOMOLOG 1; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..922
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029497586"
FT DOMAIN 821..884
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 543..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 100010 MW; 5157B0ECB2631D31 CRC64;
MLPCCKVFLL SGLAFLQPLA IGLNLPRPGC LLVLSLSHSS HSHQFYPRGK KFSLCFLKIN
DFHVDRRQLY YWRFLASPLH LLTASNCTED LEAIVLLRLF YITQANSATE IRDILRNLPS
GKYSSAGSFY SLSQVITFFL AFSPLSLQEL LPLVLMFELP IAGILQPIPD PNSPTLQHIS
QTYNISVSFK QRSRMYGATV IVRGSQNNSS AVKEGTAMLL EHLAGSLASA IPVSTQLDIA
TQHHLFMMGR NGSHVKQIMQ RTGAQIHFPD PNNPQKKSTV YLQGTIESVC LARQYLMGCL
PLVLMFDMKE EIDVEPQFIA QLMEQLDVFI SIKPKPKQPS KSVIVKSVER NALNMYEARK
CLLGLESSGV TITTSRSPVS CPAGLSCPGL DILASAGLGL TGLGLLGPTA LSVNTSTTPN
SLLNALNSSV SPLQSPSSGT PSPTLWAPPL ANPSSAAGFP ALPHLMIPST AQATLTSILL
SGVPSYSQTT PSPPPGLTPV EVHVNGMQSE GPQGSPALNG HVQSSKIKYG AISTSSLGEK
VLTGNHGDLS RQTNASEQVS SKSGASEGCN DAFVEVGMPR SPSHSANTAE LKQMMTSSKV
SCSKRQTVEL LQGTKNSHLH TAERLLSDPE LSASESPLAD KKAPGSERAA ERAAAAQQNS
ERVRLTPRSS YVNMQAFDYE QKKLLATKAM LKKPVVTEVR TPTNTWSGLG FSKSMPAETI
KELRRANHVS YKPTMRTTYE GSSMSLSRSN SREHLGSGSE SDNWRDRNGI GPTPHSEFTT
SLGSPKRKQN KSTEHYLSSS NYMDCISSLI GSNGCSLNSS LKGSDLPELF SKLGLGKYTD
VFQQQEIDLQ TFLTLTDQDL KELGITTFGA RRKMLLAISE LNKNRRKLFE PPNTRASSLE
GGASGRLPRQ YHSDIASVSG RW
//
