ID G3WFL1_SARHA Unreviewed; 759 AA.
AC G3WFL1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO7 {ECO:0000313|Ensembl:ENSSHAP00000014216.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014216.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000014216.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000014216.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; G3WFL1; -.
DR Ensembl; ENSSHAT00000014334.2; ENSSHAP00000014216.2; ENSSHAG00000012152.2.
DR GeneTree; ENSGT00940000158551; -.
DR HOGENOM; CLU_006685_0_1_1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF22; ANOCTAMIN-7; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 215..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 295..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 401..422
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 521..544
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 577..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 656..681
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 43..204
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 207..382
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT DOMAIN 389..699
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 733..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 88363 MW; 0F911AD657414920 CRC64;
NQKSESLNPE TKLFIRWKST SLHDCPQLMC FLLFFFQHLV KSGKRSIHYV LLHAPWIVLC
YYAEALRIKM PLQALPTQSS HGSTKLMRKL GIWNPLDEEV PDRPRDYYTC QFKGTNASLH
HPLTSPSIPQ LSEILEKTSF GHERKGLFGI EHLLSEKVFK AAFPPHDGPF QIPPEGLAPE
EMNQRQILYH YWAKWSKWMK YQPLHHVRRY FGEKIAFYFA WLGFYTAWLL PASLVGVVVF
LVGCFTVSMD IPTQDICDIE QDRWMCPLCS DCPFWKLSSI CKITKISRLF DNSGTVFFSV
FMSLWAVTFL EYWKRRSARL AHLWDCYDYK DYEEQPRPKF VVMAPMTTRN LVTNLEEPFF
PKKSYFQRAF MSASIIIAMV ALPCPGCREM HKTQSKFEDS FVLKVFIFQF VNINSFLIYI
AFFKGRFSGY PGNYRTFFGI QNENCINGSC FVDLAQEMLI IMVGRQIFIS LLEIFIPKLQ
VWRHRKNLYA KQNKKKEEEN SNSLGETNYE LLKYEGLFEE YLEMVIQFGF ITIFVVACPL
APLFTLLNNW IEIRLDAQKF VCQYRRPVAE KAQNIGIWFQ ILQVLTHLAV LSNALLIAFT
SDFLQRTYYQ YTHSYDLHGY INFTLAQAPK AFVLVSNHTC RYQAFREGSG KRSFTFWNLL
AIRLAFIIIF EHVIFPVAWL INVLLPDVPE SVKVKVKQEY FLAKQALADH EVPQPSPSWK
LPSALAVGVG ARRGRAALQR PPSFPRGSRP AARSPFPWV
//
