ID G3WHJ2_SARHA Unreviewed; 651 AA.
AC G3WHJ2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN Name=ZDHHC1 {ECO:0000313|Ensembl:ENSSHAP00000014897.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014897.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000014897.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000014897.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the TPPP family.
CC {ECO:0000256|ARBA:ARBA00010994}.
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DR AlphaFoldDB; G3WHJ2; -.
DR Ensembl; ENSSHAT00000015022.2; ENSSHAP00000014897.2; ENSSHAG00000012709.2.
DR GeneTree; ENSGT00940000159191; -.
DR HOGENOM; CLU_020283_0_1_1; -.
DR InParanoid; G3WHJ2; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0015631; F:tubulin binding; IEA:InterPro.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:1905668; P:positive regulation of protein localization to endosome; IEA:Ensembl.
DR GO; GO:0032461; P:positive regulation of protein oligomerization; IEA:Ensembl.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR InterPro; IPR008907; TPP/p25.
DR PANTHER; PTHR12932; P25 ALPHA-RELATED; 1.
DR PANTHER; PTHR12932:SF16; TUBULIN POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3; 1.
DR Pfam; PF01529; DHHC; 1.
DR Pfam; PF05517; p25-alpha; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW Membrane {ECO:0000256|RuleBase:RU079119};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 50..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 173..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 240..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT DOMAIN 129..281
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 71729 MW; D8114B3E39796212 CRC64;
MNICNKPSNK TAPEKSEWTI SDKSSGPSPE ICGQRSRRNG WSWPPHPFQI VAWLLYLFFA
LIGFGILVPL LPHPWVPAGY VCMGIVFLCH LVVHLTAVSI DPADANVRDK SYAGPLPIFN
RSQHAHVIED LHCNLCDVDV SSRSKHCSAC NKCVCGFDHH CKWLNNCVGE RNYWLFLNSV
VSALLGVLLV VLIAFYIFVE FFINPMRLRT NKHFEVLKNH TDVWFVFLPA APVETQAPAI
LALAALLILL GLLSVVLLGH LLCFHIYLIW HKLTTYEYIV QQRPPKEVKE TQKEPKMRPM
QEVEFYVRSF SYTNSEPQPE GLAVAASKTD HSSLFVTSAE AALPSKPDTP VLPPKIQPQK
RKKKKRKVYK VPALVASDKS QSCPPPRPGL PAPHPELPEA GAASSSSHSS NSSLHLPMPA
FLGPASSVQA AGPPAEYHSE SAESMEEIPV AQTRLGSSTA AEAGRPAPYS SLGLSRHHLP
QAPNLGKSCP EIRDYEQELE IVAKVTTVFV SQSSGEPPGP SRGQQCSGAR LDPRPEVSMA
EHPDVEGLEE SFRKFAIHGD TKATGQEMNG KNWAKLCKDC KVADGKNVTG TDVDIVFSKV
KGKTARVINY EEFKKALEEL AAKRFKGKPK EEAFNAICKL VAGKERQRGA L
//
