ID G3WIV7_SARHA Unreviewed; 1893 AA.
AC G3WIV7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN Name=NLRC5 {ECO:0000313|Ensembl:ENSSHAP00000015362.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015362.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000015362.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000015362.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012409281.1; XM_012553827.1.
DR STRING; 9305.ENSSHAP00000015362; -.
DR Ensembl; ENSSHAT00000015489.2; ENSSHAP00000015362.1; ENSSHAG00000013094.2.
DR GeneID; 100920685; -.
DR KEGG; shr:100920685; -.
DR CTD; 84166; -.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000160652; -.
DR HOGENOM; CLU_002522_1_0_1; -.
DR InParanoid; G3WIV7; -.
DR OMA; AQQDETW; -.
DR OrthoDB; 3512553at2759; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.533.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 7.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041210; NLRC5_atypical_Card.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF284; RIBONUCLEASE_ANGIOGENIN INHIBITOR 1; 1.
DR Pfam; PF18461; Atypical_Card; 1.
DR Pfam; PF13516; LRR_6; 8.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR SMART; SM00367; LRR_CC; 10.
DR SMART; SM00368; LRR_RI; 18.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 4.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 234..323
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1893 AA; 211833 MW; 544D31BBE167C0F4 CRC64;
MDSLSWQNDE ESLQQHLVGF LSKDLEWLIL KVKFFLPDLD LTPVDDLPDP TQKVSLLLDK
LRAHSLSTWR TFIHCVCMEH TMPLHLETML LSVWGMHSEI PSQNIFCKDA LPKSQLLHSG
VKRPSSEIGS SPPRKWSRQQ QLELVRKYEK RLRTLFLKKY EDVPGRTSGQ WQQWPFCFSQ
TYVDPVVRPG KVAWLKEGPE KSQVETLAEP LEVEDGANFK VQDLFRGQSG SGTKVTVLLG
KPGTGKSTLV QRICRKWARG ELDRFSQVFL FEFRQLNLVK QELTLPQLLF EVYENLEEEP
GAVFQHLQEN DHQVLLIFDG LDECLFPWPG RGPCARDSQD PFLSRPVASL FCSLCSGSLL
PGCWVVTTSR PGKIPDFLLE TATSVFEVWG FDQLRIENYV NNFFQGLISP ERALACLRAS
AQLQSLCSNP ALCSIACFCL HHLLCQDHTI KFPTTVTQLF TQMLHIFVGQ KQGTPGDKGT
WLSKDSQALL GLGELAFKGL NEKQIVFYPG HIPEQVVAFA ATYNLLSSFS VRTGTGQRDT
CYAFVHFSLQ EFFAALYLMV SPSIDSSKLR HHFYLKSRWP LRTEAKTELL DRFHTFLSGF
SSQTYLSFLT RLSQQGRAWV STKQAAVRQV LRGLATQSLT GPKMIELCHC VGETQDPELM
GQAGRSLPFS LDFHNFPLNH SDLTALTSLI NHAPASIYLN FSGCSLESQC LNALTGCGKI
ESFRVRSRKC RDAFAEALSK ILPTMGNLKK LELTGNNISV QGIDHLAQAF TDCLQLEEIN
LQDNRLNDSS CLKIITILHK MQRLQKIDLS QNAVSVQTVL ALAKEAVSYP RVTTLEIRQA
QMILLFFVSS GKALEMQRSQ NVKKNEPSDK IVTQDRKLTF RLQKCNLAVH HAKEIAEMLK
HRPYLEEVDL SGNHLEDEGC RELAEALPDL QIAKQFNISD NGLSESGVYY LLTSANACKN
VMELDISLKN KTAVFKFAGD QEKDQAPLGA AVSNPQLSSN SSEPVSSLSA RVIRLRHCGF
QCRELEKLCL KLGNCSHLDL SNNRLGNKGI EKLIQLLPSL RSLQFLTLND NRVSLKAVFC
LASTFSDLEW VHEVDISLGR QQSIHVRFLE RTRKRSVSEE WTKQKTQQES LEWGAQFPKS
FCLRECQLEP PVLEKLIQIL KTCQGLLEIK FSHVTMNDQS IGMLLNHLPQ FHNLNLVQFS
QTTLSLNSVF SLASAISLCE QIQKMEVRSL KYACLYFTPG KRKGVSCGLT DCCINQMDMK
QLCCILGQCK DLSHLNLSGN LLGDEGLKYL LEHLPQMNLS GSLNLSHNGI SEEGALLFTV
ALGTCRQAHE VSVSLNLEQK LLIHFTEHQE PRKTLRLTGF NLQQEQIKKL ATLVGQVPKL
NDLILATNTM SLAGLQLLLN SVRMPSGILR ISVEEPWVTR TSVTTLLEAS VQASGNITKI
SICRQQSLLQ IEETFPQKTG NFAADTLRPI QCDQGASLTF PYDLSQCDQG DNQTLVLRQM
VEKYMRLQEL SWSQVYLCDT SSQLLKTLFP SLLELKKFSL TASTVSPEGV CHVASGLSHC
NTMEELDLSK NEFSVEGTRV LIGALEGKCQ LRSLNLSFLQ LDNLALSELA QRLQGMSLLQ
KLDLSHSGLS SESCFSLSDS LKDATNLKDL NLSHNKIEDA GVQHLSAILP KLLQLSKLDL
SWNSISPAGG RTLAEALACC EQVEELHLGA NTMGDLMAIR LAQNLPPHLK ILYLCSNKIG
AKGTLSLGQA LVRCQWIEEI SLAENIFAEW ILPLSKGLLK LRKINLTSCR INDQMIKPLA
SSLVLCHDLE EILLAWNSLG NEGATELAYI LPQMKALKKF DLEGNQIGSL GAQLLAKGLA
KNPGIQVIRL WKNPVPKDTA QLLQGQDPRL NFS
//
