ID G3WJ83_SARHA Unreviewed; 675 AA.
AC G3WJ83;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK6 {ECO:0000313|Ensembl:ENSSHAP00000015488.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015488.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000015488.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000015488.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003756039.1; XM_003755991.1.
DR AlphaFoldDB; G3WJ83; -.
DR STRING; 9305.ENSSHAP00000015488; -.
DR Ensembl; ENSSHAT00000015615.2; ENSSHAP00000015488.1; ENSSHAG00000013200.2.
DR GeneID; 100924604; -.
DR KEGG; shr:100924604; -.
DR CTD; 56924; -.
DR eggNOG; KOG0578; Eukaryota.
DR GeneTree; ENSGT00940000156528; -.
DR HOGENOM; CLU_000288_26_6_1; -.
DR InParanoid; G3WJ83; -.
DR OMA; ARRQTMW; -.
DR OrthoDB; 460351at2759; -.
DR TreeFam; TF105352; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0140058; P:neuron projection arborization; IEA:Ensembl.
DR GO; GO:1990138; P:neuron projection extension; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06659; STKc_PAK6; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR035066; STKc_PAK6.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF19; SERINE_THREONINE-PROTEIN KINASE PAK 6; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 12..25
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 401..652
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 430
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 675 AA; 74716 MW; 8C92B38DF03C4C43 CRC64;
MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT
RVQLQPMKTV VRGSTIEVEG YISGLLNDIQ KLSVISSNTL RGRSPTSRRR AQSLGLLGDE
RWGPDTDMYL QNPQPQGADP YGIYLNCNGG TKAGRREMMW PEYQADQAQP NGLVMKTQSL
GPTEFQGAAQ RCLQLTSCLP SSSLGTSPAL PSSRGGKVGR QNSEDRRPQS CLVGPAGGRP
SGEGSPSPKT QESSLKNKLF RSMFITDGNS KPVPAAKSKP IPLFRSTQKD SPPSLPAKAQ
SLISDQSVGD FNNLIISETS SPQKSLRTVP AAVPPLGRPS PAGSPRTRHP QTSASNLHLP
QDPAAAKALV PTGEEPGIVT HEQFKAALRM VVDQGDPRLL LESYVKIGEG STGIVCLARE
KHSGRQVAVK MMDLRKQQRR ELLFNEVVIM RDYQHVNVVE LYKSYLVGEE LWVLMEFLQG
GALTDIVSQV RLNEEQIATV SESVLQALAY LHSQGVIHRD IKSDSILLTL DGRVKLSDFG
FCAQISKDVP KRKSLVGTPY WMAPEVISRS PYTTEVDIWS LGIMVIEMVD GEPPYFSDSP
VQAMKRLRDS PPPKLKNSHK ASPVLRDFLE RMLIRDPLDR ATAQELLDHP FLLQTGLPEC
LVPLIQLYRK RTSTC
//
