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Database: UniProt
Entry: G3WJV3_SARHA
LinkDB: G3WJV3_SARHA
Original site: G3WJV3_SARHA 
ID   G3WJV3_SARHA            Unreviewed;       861 AA.
AC   G3WJV3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   08-NOV-2023, entry version 65.
DE   RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A4 {ECO:0000313|Ensembl:ENSSHAP00000015708.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015708.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000015708.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000015708.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; G3WJV3; -.
DR   STRING; 9305.ENSSHAP00000015708; -.
DR   Ensembl; ENSSHAT00000015836.2; ENSSHAP00000015708.2; ENSSHAG00000013387.2.
DR   eggNOG; KOG0236; Eukaryota.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; G3WJV3; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0015111; F:iodide transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        186..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        267..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        350..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        379..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        426..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        466..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        560..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          616..810
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   861 AA;  94501 MW;  47FB0922271F3A7E CRC64;
     MGKGTPRGKV SGRGGGGGGE TARQRCALGA ARSPRAFLFG GVKGVGKEGE APALRSGAKG
     RSLCPPASLS SFPLTPHLPF SSPRMAASGR LDPELPEYRN YVVSRPVYSE LSFLEQYERQ
     LRERRTVRDK LAKCCSCSRK RTVRLLKSFF PILEWLPKYR VKEWLLSDTI SGISTGFVAT
     LQGMAYALLA AIPVGYGLYS AFFPILTYFI FGTSRHLSIG PFPVVSLMVG SFVLSMAPDE
     HFIIMNSNGT EHNVTGIDFA ARDAQRVLIA STLTVLVGII QLVLGGLQIG FIVRYLADPL
     VGGFTTAAAF QVLVSQVKIV LNISTKNYNG VLSIIYTLVE IFENIGSTNI ADLVAGLLTI
     IICMVVKEIN DRFKHKIPVP IPIEVIVTIV ATAISYGVDL EKKYNAGIVK SIPRGFLPPA
     VPSVNLFSQM ATASFSIAVV AYAIAVSVGK VYATKYDYTI DGNQEFIAFG ISNIFSGFFS
     CFVATTALSR TAVQESTGGK TQVAGLISAL IVMVAILALG KLLEPLQKSV LAAVVIANLK
     GMFMQISDVP RLWRQNKIDA IIWVFTCITS IILGLDLGLL CGLLFGLLTV VLRVQFPSWN
     DLGNVPGTDL YKSPKDYKNV DEPEGVKIVS FHSPIFYGNI DGFKKCLKST VGFDAVRVYN
     KRLKALRKIQ KLVKKGQLRA TKNGIVSDAC AINQGFEPDE DPEDPEDLDI PTKEVEIRVD
     WNSELPVKVN VPKVPIHSLI LDFGAVSFLD IVAVKSLRMI VKEFQRIDVN VYFASLKDHV
     IAKLEQCGFY EDNIIKDMFF LTVHDAVLYI QSQMKTQTAE DPILEKIHLI QEYKDPLELM
     DREMIEDGLD VQDEAMRKLA S
//
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