ID G3WK22_SARHA Unreviewed; 556 AA.
AC G3WK22;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Sorting nexin 25 {ECO:0000313|Ensembl:ENSSHAP00000015777.2};
GN Name=SNX25 {ECO:0000313|Ensembl:ENSSHAP00000015777.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015777.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000015777.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000015777.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3WK22; -.
DR STRING; 9305.ENSSHAP00000015777; -.
DR Ensembl; ENSSHAT00000015906.2; ENSSHAP00000015777.2; ENSSHAG00000013443.2.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_005899_1_1_1; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 58..172
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 279..422
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT COILED 205..267
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 556 AA; 64886 MW; 16622D8F10090134 CRC64;
MKADLLRARN MKRYINQLTV AKKQCEKRIR LLGGPAYDQQ EDGVSDEGEG PQSQKILQFE
DILANPCYRE HFRIYMERMD KRALISFWES VEYLKNANKN EIPQLVGEIY QNFFVESREI
SVEKSLYKEI QQSLVGNKGI EVFYKIQSDV YESLKDRYYP SFIVSDLYER LIKKEEEKSV
SQLISDKDEA SQGGEVGEET IEEANDRINE QASYAVNKLR ELNEKLDYKK QALHSIQNAP
KPDRKIVSKL KEEIILMEKE RNDLQLHIAR TDWWCENLGM WKAFINSGEV LEENGEQMPC
YFVMVSLQEV GGVETKNWTV PRKLSEFQNL HRKLSECFPS LKKVQLPSLS KLPFKSVDHK
FMEKSKNQLN TFLQEEAEED SDLSDYGDDV DGKKDALAEP CFMLIGEIFE LRGMFKWVRR
TLIALVQVTF GRTINKQIRD TINWIFSEPM LVYYINVFRD AFWPNGKLAP PMPPRSEEQS
QETKQRAQQK LLENIPDMLQ SLVGQQNARH GIIKIFNALQ ETRANKHLLY VLMELLLIEL
CPELKIHLDQ LKAGQV
//
