ID G3WKS3_SARHA Unreviewed; 490 AA.
AC G3WKS3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Protein kinase domain containing, cytoplasmic {ECO:0000313|Ensembl:ENSSHAP00000016028.2};
GN Name=PKDCC {ECO:0000313|Ensembl:ENSSHAP00000016028.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016028.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016028.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016028.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3WKS3; -.
DR STRING; 9305.ENSSHAP00000016028; -.
DR Ensembl; ENSSHAT00000016160.2; ENSSHAP00000016028.2; ENSSHAG00000013649.2.
DR eggNOG; KOG1187; Eukaryota.
DR GeneTree; ENSGT00390000001205; -.
DR HOGENOM; CLU_044025_0_0_1; -.
DR TreeFam; TF329248; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR042983; PKDCC.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR46448:SF3; EXTRACELLULAR TYROSINE-PROTEIN KINASE PKDCC; 1.
DR PANTHER; PTHR46448; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12260; PIP49_C; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..490
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029463465"
FT DOMAIN 135..423
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 29..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..119
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 54500 MW; 22219C6A7D93A7EC CRC64;
MRRRRAAVAA GFCASFLLGS VLNVLFVPGS EPPRPGQPPG PSPAPAPGRR GGRGELARQI
RARYEEVQRY TRGGPGPGAG RPERRRLMDL ARSGPGLQRP RPPRVPRART PPDGTLGWPP
APDPPRLGCA ALRNVSGAQY VGSGYTKAVY RVRLPGGVAV ALKAVDFSGH DLGSCVREFG
ARRGCYRLAA HKLLKEMVLL ERLRHPNVLQ LYGYCYQDSE DIPDTLTTIT ELGSPVEMIQ
LLQTSWEDRF RICLSLGRLL HHLAHSPLGS VTLLDFRPRQ FVLVDGELKV TDLDDARIDE
TPCESPGDCV LEFPARNFTL PCSAQGWCQG MNEKRNLYNA YRFFFTYLLP HSAPPSLRPL
LDSIVNATGE LIWGVDETLV QLEKVLHLYR SGQYLQNSTT SPRAEYRRVP DTTIPQENYH
CWPSYHHGGC LLSVFSLAEA MDVCESHSQC RAFVVTNQTT WTGRQLVFFK TGWSQIVSDP
NKITYVRASA
//
