ID   G3WKS8_SARHA            Unreviewed;       302 AA.
AC   G3WKS8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Phosphopantothenoylcysteine synthetase {ECO:0000313|Ensembl:ENSSHAP00000016033.2};
GN   Name=PPCS {ECO:0000313|Ensembl:ENSSHAP00000016033.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016033.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000016033.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000016033.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PPC synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005703}.
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DR   AlphaFoldDB; G3WKS8; -.
DR   STRING; 9305.ENSSHAP00000016033; -.
DR   Ensembl; ENSSHAT00000016165.2; ENSSHAP00000016033.2; ENSSHAG00000023974.1.
DR   eggNOG; KOG2728; Eukaryota.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_042326_3_0_1; -.
DR   TreeFam; TF105615; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.10300; CoaB-like; 1.
DR   InterPro; IPR035929; CoaB-like_sf.
DR   InterPro; IPR007085; DNA/pantothenate-metab_flavo_C.
DR   PANTHER; PTHR12290; CORNICHON-RELATED; 1.
DR   PANTHER; PTHR12290:SF2; PHOSPHOPANTOTHENATE--CYSTEINE LIGASE; 1.
DR   Pfam; PF04127; DFP; 2.
DR   SUPFAM; SSF102645; CoaB-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN          36..84
FT                   /note="DNA/pantothenate metabolism flavoprotein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04127"
FT   DOMAIN          157..266
FT                   /note="DNA/pantothenate metabolism flavoprotein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04127"
SQ   SEQUENCE   302 AA;  32749 MW;  FA1172F39C279929 CRC64;
     MAEAILGSEF PEPPGVARNA ALMQRFAAQL GAQGRRVVLI TSGGTKVPLE ARTVRFLDNF
     SSGRRGAASA ESFLRAGYGV LFLHRARSAF PFAHHFPPQA WLSALRPARS EPEGPGGRLL
     LEAEAAALPG FADALLSYQD AANAGTFLAV EFTTLNDYLH LLQAAAQALS PLGSNAMFYL
     AAAVSDFYVP ASEMPEHKIQ SSGGPLQITM KMVPKMLSPL VKDWAPKAFV ISFKLETDPS
     VVIDHARKAL ETYCHQVVVA NILESRRSYV VIVTKDSETQ LSLSDEEMEK GKCSIRRHTS
     FS
//