ID G3WMP2_SARHA Unreviewed; 481 AA.
AC G3WMP2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Synaptotagmin 6 {ECO:0000313|Ensembl:ENSSHAP00000016697.2};
GN Name=SYT6 {ECO:0000313|Ensembl:ENSSHAP00000016697.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016697.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016697.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016697.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996}.
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DR AlphaFoldDB; G3WMP2; -.
DR STRING; 9305.ENSSHAP00000016697; -.
DR Ensembl; ENSSHAT00000016838.2; ENSSHAP00000016697.2; ENSSHAG00000014204.2.
DR eggNOG; KOG1028; Eukaryota.
DR GeneTree; ENSGT00940000157665; -.
DR HOGENOM; CLU_023008_8_0_1; -.
DR TreeFam; TF315600; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd08385; C2A_Synaptotagmin-1-5-6-9-10; 1.
DR CDD; cd08403; C2B_Synaptotagmin-3-5-6-9-10; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF45; SYNAPTOTAGMIN-6; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 146..267
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 278..411
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 54565 MW; 18720082AEA89FD5 CRC64;
MPWRNKEASS PSSTNPTLAA PQSPSLSPRD TMADKVKDPN ALGFLEAAVK ISHTSPDIPA
EVQMSVKEHI MRHTRLQRQT TEPASSTRHT SFKRHLPRQM HVSSVDYGND PPPAAEQPTS
IGRIKPELYK QKSVDDEEGK NEAAKTCGKI NFSLKYDYEN ETLVVRILKA FDLPAKDFCG
SSDPYVKIYL LPDRKCKLQT RVHRKTLNPT FDENFHFPVP YEELADRKLH LSVFDFDRFS
RHDMIGEVIL DNLFEASDLS RETSIWKDIQ YATSESVDLG EIMFSLCYLP TAGRLTLTVI
KCRNLKAMDI TGYSDPYVKV SLLCDGRRLK KKKTTIKKNT LNPIYNEAII FDIPPENMDQ
VSLLISVMDY DRVGHNEIIG VCRVGISAEG LGRDHWNEML AYPRKPIAHW HSLVEVKKSF
KEVGLAPLGP LDCMGCAWLI WLENGNQLFF RFKTFPGKKG SGGPCVEVYG VFPPIFFFLF
V
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