ID G3WN28_SARHA Unreviewed; 575 AA.
AC G3WN28;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Ring finger and SPRY domain containing 1 {ECO:0000313|Ensembl:ENSSHAP00000016833.1};
GN Name=RSPRY1 {ECO:0000313|Ensembl:ENSSHAP00000016833.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016833.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016833.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016833.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003757323.1; XM_003757275.2.
DR RefSeq; XP_012409295.1; XM_012553841.1.
DR AlphaFoldDB; G3WN28; -.
DR STRING; 9305.ENSSHAP00000016833; -.
DR Ensembl; ENSSHAT00000016975.2; ENSSHAP00000016833.1; ENSSHAG00000014318.2.
DR eggNOG; KOG2242; Eukaryota.
DR GeneTree; ENSGT00940000157894; -.
DR HOGENOM; CLU_026400_0_0_1; -.
DR OMA; KYSHDSV; -.
DR TreeFam; TF313546; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16566; RING-HC_RSPRY1; 1.
DR CDD; cd12883; SPRY_RING; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR045129; RNF123/RSPRY1-like.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035774; SPRY_RSPRY1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13363:SF6; RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003458986"
FT DOMAIN 299..482
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 526..561
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 49..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 64516 MW; 455543C771252416 CRC64;
MIVFAWVVFY ASRSLVQGLL LTLEQHISSF LGTLGATNMG NSCICRDDSG TEDNAESQHQ
QSENSILPAA ENRSHLRDPV RPPRRGRGPH EPRRKKQNVD CLVLDTLAVI RTLVDNDQEP
PYSMITLHEM AETDEGWLEV VQSLIRVIPL EDPLGPAVIT LLLDECPLPT KDALQKLTEI
LNLNGAVACQ DASHPAKHRN TTAVLGCLAE KLAGPASINL LSPGILEYLL QSLNFQSHPT
VMLFALIALE KFAQTSENKM TISKSCISDR LVMLESWTEN SDYLKRQVGF CAQWSLDNLF
LKEGRQFTYE KVDLTNIRAM LNSNDVSEYL KISPHGLEAR CDASSFESVR CTFCVDSGVW
YYEVTVITSG VMQIGWATKD SKFLNHEGYG IGDDEYSCAY DGCRQLIWYN ARSKPHSHPC
WKEGDTIGFL LDLQEKQMIF CLNGSQLPSE KQVFTSAVSG FFAAASFMSY QQCEFNFGAK
PFKYPPSIKF STFNDYAFLS PEEKIILPRH RRLALLKQVS IRENCCSLCC DEVADTELKP
CGHSDLCMDC ALQLETCPLC RQEIVSRVRQ ISHIS
//
