ID G3WNC9_SARHA Unreviewed; 1639 AA.
AC G3WNC9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Kinesin family member 14 {ECO:0000313|Ensembl:ENSSHAP00000016934.1};
GN Name=KIF14 {ECO:0000313|Ensembl:ENSSHAP00000016934.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016934.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016934.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016934.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSSHAT00000017076.2; ENSSHAP00000016934.1; ENSSHAG00000014403.2.
DR GeneTree; ENSGT00940000156834; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22707; FHA_KIF14; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 350..693
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 817..868
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 242..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 704..785
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 921..1063
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 242..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 439..446
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1639 AA; 187120 MW; 8A856A38BC14E9FB CRC64;
MSMYNTTFIQ NRNDAFGLSS QNKSSLTALN QSSRLKQHMK SEIPECENDD SLSKSLNKIK
EVNRTYVISA CKKVPEVSLT PNLEGKLALQ RRTRKIQEQP LLGSQLQEET TGKLTLQRRI
TTDTLEKCKT NKNVPNGVYN EKSGLQQSNK SVKTANTDKL SLGKSVSSVV EDIKQKNPPI
DEKNNEKFSI PRAENGNLLH DRSSVFQAVE PQSQNEVSRL GHSAGMKPMQ NSSDVKITTT
GNLSHRSVGK ETTKNLNNKF GSMEKPRTPR QWIMEESKFT PKSSIPQGRV TALSIPKNRT
CLQIVQKQKS TPSSFLENKR ERSQENTLLR EETTQNTYRQ SNLLKVENSQ VIVAVRVRPF
SSREKTDNAS QVVFMNGQET TVQHPDMKQN YNFVYDFSFW SFDKCHPNYA SQSTVYETLA
VPLLERAFEG YNTCLFAYGQ TGSGKSYTMM GFGEELGIIP RFCEDLFSQI AKKETQEVSY
HLEMSFFEIY NEKIHDLLVC KAENGQKKQP LRIREHPVSG PYVEALSVNV VSSYSDVQGW
LELGNKQRAT AATGMNDKSS RSHSVFTLVM TQTKTEFVED EEHDHRIISR INLIDLAGSE
RCSTTRTSGE RLKEGVSINK SLLTLGKVIS ALSEQANRKR VFIPYRESVL TWLLKESLGG
NSKTAMIATI SPAASSIEET LSTLRYAKQA GLIINIAKVN EDVNAKLIRE LKAEIEKLKA
TQRNTRNIDP ERYRRCQQEI TSLRMKLHQQ EKEIAEMHRA WREKLEQAEK RKLQETKELQ
KAGITFKMDN RLPNLVNLNE DPQLSEMLLY MIKEGKTTVG KYKPNSDHDI QLSGVLIADD
HCIIKNFDGT VSIIPLGDAK TYVNGKHISE STILHHGDRV ILGGDHYFRF NHPVEVQKGK
ISFCGSLLTN DCPKDFEFAK NELLMAQRSQ LEAEIEEARL KAKEEMMQGI QIAKEMAQQE
LSSQRAAYEN KIKALETELK EESERKKMQE INNQKANDKI QELEKAKQHL EQKVHANKKR
LEMETLATKQ ALEDHTVRHT KILEALEAEK QKIVKEVQIL QQNRNNKDKM LTIQPNWNFM
KLSMMIQEAN TISNKLRKCY VFYRHDISSE GNTIEPFVQV QIRNVQLGIS TFWSLEKFES
KLAAMKELYE NNSSVKSEDI FYDPEDEWEP DLANTTVSSF SRRRSRSLMK NRRISGCLQD
IKVHPVQNLN STSGLMEKSD SIYSNSTESF LPGICKELIG SALDFLSQND EEKTMEDSLI
TSFLKIHSCM IAISKAYEQQ DEESQDNFFS TDRATQLFCI QMTSAFEQLV VLTKHWLNDF
PQSTSIPDDD LTQEVKKLGG YLQLFLQGCC SDISSMVNEV QKKIIQTVLQ GLRYVGQIAV
LKGAKFHLSE NNRDKMVNLQ EDFINAICDG VRFGLNTLLN SGLEKIRQLL HELELFRQQC
SQNKVLEKMK TNAMALTRFF ENTIADWKKK GFRAQVKEEE SVYQGAEKLI NFATEFLKLK
HCLEQISQIV ISTLKGLGSS SDVILLKNCV ENICILAKHF NDNFSLFTSL SDSTSAHDDR
ISDVDFREIQ SLAKSLLLDF ESEEQLYLLK PKEISKQNSK DEEKYKLIRT DEPKYDCKFQ
IPSSALCTEE LSPNNIEWV
//
