ID G3WPP0_SARHA Unreviewed; 512 AA.
AC G3WPP0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Tubulin-specific chaperone E {ECO:0000256|ARBA:ARBA00015004};
DE AltName: Full=Tubulin-folding cofactor E {ECO:0000256|ARBA:ARBA00030180};
GN Name=TBCE {ECO:0000313|Ensembl:ENSSHAP00000017395.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017395.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000017395.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000017395.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TBCE family.
CC {ECO:0000256|ARBA:ARBA00006286}.
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DR AlphaFoldDB; G3WPP0; -.
DR Ensembl; ENSSHAT00000017540.2; ENSSHAP00000017395.2; ENSSHAG00000014780.2.
DR GeneTree; ENSGT00530000063405; -.
DR HOGENOM; CLU_017716_5_0_1; -.
DR OrthoDB; 11880at2759; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043014; F:alpha-tubulin binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd17044; Ubl_TBCE; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR044994; TBCE.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR044079; Ubl_TBCE.
DR PANTHER; PTHR15140; TUBULIN-SPECIFIC CHAPERONE E; 1.
DR PANTHER; PTHR15140:SF31; TUBULIN-SPECIFIC CHAPERONE E; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 27..71
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
SQ SEQUENCE 512 AA; 57503 MW; F7A295FB5EBFEA95 CRC64;
MSDSVPSDVI GRRIDVNGEL GTVRYFGDVP PVKGPWIGIE WDNPQRGKHD GSHEGTIYFK
CRHPTGGSFI RPNRVNFGVD FLTAIKNRYG LENTKEEDGN EMIVIGNKPV ETVGFDSIKK
FQSQLNRLQE VSVWSSAVSC AGNKGEIAQT CPNIRRIDLS KNLLSSWNEV ISIAAQLKYL
EVLNLSENKL KFPYDSPSPS FTFSALKVLV LNRTGITWTE VLWCAKGWPV LEELYLASND
IIISERPTDT LQTLKLLDLS NNQPIDGDQL FQIAYLPRLE QLILSDNRIS ALHFPDAGIG
CKTSMFPSLQ YLVINGNQIS QWSSINELDK LQSLQSLSCT QNPLTGGNKE PQTIRQVIIA
KIGQLKILNK CEILPEERRG AELDYRKTFG NEWKKAGGHQ DPDKNKPNNE FITAHPRYQL
LCLKYGAPED GELKPQQPFM LKNQLLTLTI KCLNQPDQKA LVKQLPESMT IQKVKGLLSR
LLKVPGSELR LSYESPKVSS SIRPIIKFCP SL
//
