ID G3WPY8_SARHA Unreviewed; 631 AA.
AC G3WPY8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=MAGUK p55 scaffold protein 4 {ECO:0000313|Ensembl:ENSSHAP00000017493.2};
GN Name=MPP4 {ECO:0000313|Ensembl:ENSSHAP00000017493.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017493.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000017493.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000017493.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR AlphaFoldDB; G3WPY8; -.
DR STRING; 9305.ENSSHAP00000017493; -.
DR Ensembl; ENSSHAT00000017638.2; ENSSHAP00000017493.2; ENSSHAG00000014864.2.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000156444; -.
DR HOGENOM; CLU_001715_5_0_1; -.
DR TreeFam; TF314263; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122:SF34; MAGUK P55 SUBFAMILY MEMBER 4; 1.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 25..80
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 81..138
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 155..236
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 243..313
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 421..610
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 631 AA; 72418 MW; 1DCB022B0ECC3665 CRC64;
FLRSEKEEKL LDKKSKMELP AVTNQENGLS QILKLVMKQQ SLFYSRDVSG VSLLYDLLHS
PWLQALLKVY ECLQEYIKKK PIPVLSQAQA LSCEVMDLLQ EVPQSPEAQE LRQVLKAKHF
QALLNAHDIV AQKDFEPVLP PLPDDIPENE EALRIVCLVK NKQPLGATIK RHEITGDIMV
ARIIHGGLAD KSGLLYAGDK LVEVNGISVE GLEPEQVIHI LAMSHGTIMF KVVPVSDRPI
YNQTMVYVRT MAKYCPWQDP IIPCADAGLP FQKGEILQIV DRNDSLWWQA RKLSDFGTCA
GLVPSNHLLK RKQREFWWSQ PFQPQTYLKS TILSTLDEED DIKIDEKCVE EEELSEDEKE
FAGYDHRFFI AGFRRSMRLC RRKSYTSQQS AYILCSNSCY NALGAPYEEV VRYQRHPSDK
HRLIVLVGPS GVGINELRRR LIETNPNYFQ SAVPHTTRSK KSYEEDGREY HYVSKETFES
LVYGHRMLEY GEYKGNLYGT SVDAVRKVLD EGKVCIMDLE PQNIQAARTH ELKPYVIFIK
PSSLNRMKQS RKNARIITDY YVNIKFKDED LQEMEDLAKK METQFGQFFD QVIVNDSLPE
ACAQLLSAVQ QAQNEPQWVP ATWICSDNES G
//
