ID G3WQ05_SARHA Unreviewed; 565 AA.
AC G3WQ05;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Embryonal Fyn-associated substrate {ECO:0000313|Ensembl:ENSSHAP00000017510.1};
GN Name=EFS {ECO:0000313|Ensembl:ENSSHAP00000017510.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017510.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000017510.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000017510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR RefSeq; XP_012400339.1; XM_012544885.1.
DR AlphaFoldDB; G3WQ05; -.
DR STRING; 9305.ENSSHAP00000017510; -.
DR Ensembl; ENSSHAT00000017655.2; ENSSHAP00000017510.1; ENSSHAG00000014878.2.
DR eggNOG; ENOG502QUFB; Eukaryota.
DR GeneTree; ENSGT00950000183008; -.
DR HOGENOM; CLU_012582_1_0_1; -.
DR InParanoid; G3WQ05; -.
DR OMA; LHNEYEG; -.
DR OrthoDB; 3030146at2759; -.
DR TreeFam; TF328782; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF14; EMBRYONAL FYN-ASSOCIATED SUBSTRATE; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 3..66
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 63..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..124
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..167
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..272
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 59418 MW; 757E0CA45B1A65AA CRC64;
MAVSAQLARA LYDNTAESPE ELSFKRGDVL RVLQGEGAGG LQGWCLCSLH GQQGIVPANR
VKLLPTGPSP ESSLYQVPPT PQSTSDSAPG PGPVEQEVYV IPPPPRPCSA PRPSPGPCPP
SPDAIYKVPR SSGTQTDTPG DTREVYDVPP TALRVPPNDP YDSPVPFPRP LTRASTQQPG
EDDAPYDVPP ALKPSPELDL EWEGGREPEP PLYAAPSNLK RASALLNLYE APEELLGEGT
SSSSDEAIYD VPLLGPEEPL PPAPPTPPGS NPAPSDLETL ALLLARSPPP PPRPRLPSTE
SLSRRPLPAL PVQELSAPSP VPSPASGRKG SIQDRPLPPP PPRLPSYMGL KTEGAEEGRV
GDAGAGTAEP HNEYEGIPLG EEYDYVHLKG MERIQGSDPL DGATLGDPEP RLRERLLQEE
QEAPTPGEPL NLPSGDLQLL HFYAGQCQSH YSALQAAVAA LLASTRANHP PRQFVPHSKR
VVVAAHRLVF VGDTLGRLAA SAPLRAQVGT AGAALGQALR AAVLAVKSAA LGYPSGPAAR
EMAQRVAELA GQALQFTTLL SGLAP
//
