GenomeNet

Database: UniProt
Entry: G3WQ55_SARHA
LinkDB: G3WQ55_SARHA
Original site: G3WQ55_SARHA 
ID   G3WQ55_SARHA            Unreviewed;       432 AA.
AC   G3WQ55;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   11-DEC-2019, entry version 50.
DE   SubName: Full=ETS variant 6 {ECO:0000313|Ensembl:ENSSHAP00000017560};
GN   Name=ETV6 {ECO:0000313|Ensembl:ENSSHAP00000017560};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017560, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000017560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000017560}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; AEFK01193589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01193598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000017560; -.
DR   Ensembl; ENSSHAT00000017705; ENSSHAP00000017560; ENSSHAG00000014916.
DR   eggNOG; KOG3804; Eukaryota.
DR   eggNOG; ENOG4111K4J; LUCA.
DR   GeneTree; ENSGT00940000159508; -.
DR   InParanoid; G3WQ55; -.
DR   OMA; IENNHCP; -.
DR   TreeFam; TF318679; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN          41..125
FT                   /note="PNT"
FT                   /evidence="ECO:0000259|PROSITE:PS51433"
FT   DOMAIN          340..421
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          157..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..246
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  51030 MW;  A06C27634E5DCF86 CRC64;
     MSETPVQCTI KQERISYTPP ESPVPNYTSS STPLHVPVPQ AIRMEEDSIR LPAHLRLQPV
     YWSRDDVAQW LKWAENEFSL RPIDSNTFEM NGKALLLLTK EDFRYRSPHS GDVLYELLQH
     ILKQRKPRIL FSPFFHPGNS LQTQPEVMLH QNHDEDNCIQ RSSRPPVENM HHNPPTIELL
     HRSRSPITTN HRPSPDPDQR PIRSPLDNMI RRLSPSERIP GPRLHQENNH QESYPLSVSP
     MENNHCPPSS EAHPKPSSPR QENTRVIQLM PSPIMHPLIL NPRHSVDFKQ SRMSEDGLHR
     EGKPINLSHR EDLAYMNHIM VSVSPPEEHA MPIGRIADCR LLWDYVYQLL SDSRYENFIR
     WEDKESKIFR IVDPNGLARL WGNHKNRTNM TYEKMSRALR HYYKLNIIRK EPGQRLLFRY
     HFLFFYYTFS RW
//
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