GenomeNet

Database: UniProt
Entry: G3WQK2_SARHA
LinkDB: G3WQK2_SARHA
Original site: G3WQK2_SARHA 
ID   G3WQK2_SARHA            Unreviewed;       404 AA.
AC   G3WQK2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   16-OCT-2019, entry version 43.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSSHAP00000017707};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017707, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000017707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000017707}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AEFK01063300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000017707; -.
DR   Ensembl; ENSSHAT00000017853; ENSSHAP00000017707; ENSSHAG00000015039.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; G3WQK2; -.
DR   OMA; WGTLINP; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001258; NHL_repeat.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF01436; NHL; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN       28     74       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   REPEAT      124    168       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      172    215       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      216    256       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      271    311       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      334    360       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
FT   REPEAT      371    404       NHL. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00504}.
SQ   SEQUENCE   404 AA;  43495 MW;  24B058266256FE9D CRC64;
     LSMSAEASER EPALRTLVRE AEISLLECKV CFEKFSHEKD RRPRNLTCGH VICLGCVTAL
     VQPRTRTLEC PFCRKAGKSS ETSDCLPLLQ FLELLGPVLR APPSSEAGAA RAPEDPAAKW
     VPGVLICSHS FGGWGTLINP TAMALCPRSE RVVIVHDGRK RVKVFDSDGI CVHQFGEKGE
     AAQEVRYPLG VTVTCDGHVV ITDAGDRSVK VFDLSGQNKL VIGNRFSLPW GVQTTPQKEI
     MVSDAGAGSL HLLVVDFQKG ELRRAERLLA HLCNPRALAV SPITGAIAVT EHRLAQGPCS
     ASTRVKVFSA GLQLLGQVDT FGLSLFIPSK IEATAVTFDH QGNVIVADTT TQAIVCLGKP
     EEFPVLKPII TQGLSYPVAL TYTEDNSLLV LDSGVHAVKV YKAG
//
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