ID G3WSV7_SARHA Unreviewed; 818 AA.
AC G3WSV7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL10 {ECO:0000313|Ensembl:ENSSHAP00000018512.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018512.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018512.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018512.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; G3WSV7; -.
DR STRING; 9305.ENSSHAP00000018512; -.
DR Ensembl; ENSSHAT00000018666.2; ENSSHAP00000018512.2; ENSSHAG00000015717.2.
DR eggNOG; KOG2210; Eukaryota.
DR GeneTree; ENSGT00940000157880; -.
DR HOGENOM; CLU_012334_3_1_1; -.
DR TreeFam; TF312807; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13291; PH_ORP10_ORP11; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF47; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 10; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 78..175
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..380
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 818 AA; 89777 MW; EB61241615840823 CRC64;
MEKAASPGAG AGEGAGSGAS SRSSSRATSA GSSPSGSWAA RGAGGRRLEG GSHSSPGSVA
ASPCGAGGRL GGGGRRREPA LEGVLSKYTN LLQGWQNRYF MLDFESGVLQ YFVNEQSKSQ
KPRGTLSLAG AIVSLSDEAP HMLVVYSANG EVYKLRAADA KEKQCWVTQL QNCAKYHMEA
HPKSPPSSRS RSLTLLPHGT SNSSSPSSQR HLIPAPSSVV TVTHHKSPAT ARRSKSQYSA
QLHDVREMMS QVEGQQKSLV RAIEALPGSG PLTALDQDLL LLKATSAATL SCLGECLSLL
QQSIHQVGQY SHRTGPSENP GWQGPKSHST ERVKNGAVGL PPSSHASVTW AALPAPTASR
DVPSKSEPKV EGEKEISTHS QHWGEQQLFP AYTPTSQHQI TSSPSVIQQE PKIGSASGSA
SQEDRTNEEE TDNEENGDEN ADNSEDHHSI VLHLISQLRF GMDLTKVALP TFILETRSLL
EMFANFMAHP DLLLSIGSAA TPEERAISFV EYYLTSFREG RKGSVAKKPY NPILGEIFHC
SWDIPKDQVK PLLREQNEAE APAPSTEPDR EHSPRERYKL RFVAEQVSHH PPVSCFYCEC
KERGMFVNTH VWTKSKFMGM SVGVSLLGEG VLRLLDYEED YIFTLPNAYA RSILTIPWVE
LGGKVTMECA KTGYTALVTF HTKPFYGGKV HRVTAEVKHK PSNTVVCKAQ GEWNGVLEFT
YSNGETKLIN TAALPVYPKK VRPIEKQEPM ESRNLWREVT NSIKVGDMNS ATEFKRNLED
KQRKEEQERA SRKAEWRPRY FNKQGEGWMY RDPLLKGQ
//
