ID G3WT76_SARHA Unreviewed; 1037 AA.
AC G3WT76;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DNA cross-link repair 1A {ECO:0000313|Ensembl:ENSSHAP00000018631.1};
GN Name=DCLRE1A {ECO:0000313|Ensembl:ENSSHAP00000018631.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018631.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018631.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018631.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
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DR AlphaFoldDB; G3WT76; -.
DR STRING; 9305.ENSSHAP00000018631; -.
DR Ensembl; ENSSHAT00000018785.2; ENSSHAP00000018631.1; ENSSHAG00000015816.2.
DR eggNOG; KOG1361; Eukaryota.
DR GeneTree; ENSGT00940000158766; -.
DR InParanoid; G3WT76; -.
DR OMA; WSSRKAM; -.
DR OrthoDB; 23465at2759; -.
DR TreeFam; TF314510; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035312; F:5'-3' DNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 115..145
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 434..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1037 AA; 117166 MW; 6BB0E0E9CA3806D9 CRC64;
MSEENLLEED IWEYKSIRKP KLGNSDVSNS VQKATNGNCK LKGCESKVKR AVKVKGKPKN
DELYLGERGS QTLVSEPNLN SASNIQQSLG KVTTKAKVGK TNKKLTPTKQ HPVYSGYCPS
CQMPFSLLLG QTPRWHVSEC LDAQQSSTRE CPDGLLCTST IPSHYTRYAH FLLAQSRAGN
DCFSSPTSMS SSKLLDSNDT KSGFLCSLEE RWTQCQKQTE NAKNVSNDPL LITLSPRKLQ
SPNETNKKIS FSTNISKSQQ TMQFTEFVDN DKLESSGLPL PHEELERQNS SEHLNLPLPE
ADLSDCEISY SPLQSDEETY DIEEQLENSQ KELFIAENSE NCSIEDEDDS CILFRRLCRT
LQEDYKPDFR KMKSAINQNK YDEELNIAHS LNDLSKSVSQ NERIKASETA CTNHFKCFSA
SLVGELNSTE YQFNKEASDE PKLLSSQSSR GNMSSEESDV CSWASQQLLN SDMSMSLESK
EENTSPESTQ SEMIKESNSS FHGKRNNHIN FCREALDSNL GNKASVLDME AFHNKTTAHM
STEVLLPCTP NSNTRPSTKV LKQMDIGVFF GLPPKAKEEK TPEKNSLKRT KKASPNEKQS
GQSKRKREGS LDDLELDIHN LNRTETSVKS SCEGSQRRKR FRKSAIIEEN TQLRETDELM
NKGEQLTNKI GRGGSQKWRK RFQDKGYSEG GLKEKKCPFY KKIPGTTFTV DAFQYGAIEG
CTAYFLTHFH SDHYAGLSKK FTFPVYCSKI TSNLVKNKLC VQEQYLHPLP MDTVCTVNGI
KVVLLDANHC PGAVMILFYL PNGTVTLHTG DFRANPSMER YSLLASQKVH TLYLDTTYCS
PEYTFPSQQE VIQFAINIAF ETVTLSPRTL VVCGTYSIGK EKIFLAIADV LGSKVSMSQE
KYKTLQCLEL QEVNSLITTD WSSALVHLLP MMQINFKGLQ NHLNKYGGKY ENILAFRPTG
WTHSEKFGSL ADIVPQTKGN ISIYGIPYSE HSSYLEMKRF VQWLKPQKII PTVNVGSWKF
RNTMEKYFNE WKHEAGY
//
