ID G3WTR0_SARHA Unreviewed; 2473 AA.
AC G3WTR0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Notch receptor 2 {ECO:0008006|Google:ProtNLM};
GN Name=NOTCH2 {ECO:0000313|Ensembl:ENSSHAP00000018815.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018815.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018815.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018815.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9305.ENSSHAP00000018815; -.
DR Ensembl; ENSSHAT00000018970.2; ENSSHAP00000018815.2; ENSSHAG00000015968.2.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000155030; -.
DR HOGENOM; CLU_000576_1_1_1; -.
DR InParanoid; G3WTR0; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR GO; GO:0046849; P:bone remodeling; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; IEA:Ensembl.
DR GO; GO:0003184; P:pulmonary valve morphogenesis; IEA:Ensembl.
DR GO; GO:2001204; P:regulation of osteoclast development; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 28.
DR CDD; cd21703; JMTM_Notch2; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 20.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 35.
DR SMART; SM00179; EGF_CA; 34.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 15.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 34.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 10.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2473
FT /note="Notch receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029508460"
FT TRANSMEM 1683..1705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..63
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 64..102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 105..143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 144..180
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 182..219
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 221..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 260..296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 298..336
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 338..374
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 375..413
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 415..454
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 456..492
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 494..530
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 532..568
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..605
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 607..643
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 645..680
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 682..718
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 720..755
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 757..793
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 795..831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 833..871
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 873..909
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 911..947
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 949..985
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 987..1023
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1025..1061
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1063..1099
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1110..1147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1149..1185
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1187..1223
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1225..1265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1267..1305
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1307..1346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1378..1415
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1423..1468
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1469..1505
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1506..1547
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1881..1913
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1948..1980
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1981..2013
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2014..2046
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1756..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2100..2182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2369..2473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1766..1792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2128..2143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2144..2182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2384..2404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2420..2449
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 436
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 456
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 459
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 473
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 497
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 511
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 512
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 53..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 73..90
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 92..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 133..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 170..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 209..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 248..257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 286..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 326..335
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 364..373
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 384..401
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 403..412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 419..433
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 427..442
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 444..453
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 460..471
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 465..480
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 482..491
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 498..509
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 503..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 520..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 558..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 574..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 595..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 633..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 649..659
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 670..679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 708..717
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 724..734
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 745..754
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 783..792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 821..830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 842..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 861..870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 899..908
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 937..946
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 975..984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1013..1022
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1051..1060
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1089..1098
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1137..1146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1175..1184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1213..1222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1255..1264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1276..1293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1295..1304
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1336..1345
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1386..1403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1405..1414
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2473 AA; 265380 MW; 75B3B94655ECE7AA CRC64;
MPALRPAPIC LLLGLWLCQG APTLAIQCRD AFKPCVNEGK CVTYQNGTGY CECPEGFLGE
YCQQLDPCER TKCQNGGTCV PLALQGKATC RCAPGFTGED CQYSTSHLCF VSRPCQHGGT
CQMRSRDTYE CICPPGRTGK HCQWVDACLS QPCANGSTCT TIANQFSCSC PAGFTGQKCD
TDLNECDVPG RCQHGGTCLN LPGSYQCQCP QGFTGQHCDS PYVPCSPSPC VNGGTCRQTD
DFTFECNCLP GFEGTTCERN IDDCPNHNCK NGGVCVDGVN TYNCRCPPQW TGQFCTEDVD
ECQLQPNACQ NGGTCTNHNG GYGCVCVNGW SGDDCSENID DCAFAACTLG STCIDRVASF
SCTCPEGKAG LLCHLDDACI SNPCHKGALC DTNPLNGQYI CTCPQGYKGA ACTDDVDECA
MANSNPCEHA GKCVNTEGAF HCECLKGYTG PRCEMDINEC HSDPCQNDAT CLDKIGGFTC
LCMPGFKGVH CELEINECQS NPCVNNGHCL DKVNRFQCVC PPGFTGSVCQ IDIDDCSSTP
CLNGAKCIDH PNGYECQCAT GFTGLLCEEN IDNCDPDPCH HGQCQDGIDS YTCICNAGYM
GAICSEQIDE CLSSPCLNEG RCIDLVNGYQ CNCQPGTSGV NCEINFDDCA SNPCVHGICM
DGINRYSCVC LSGFTGQRCN VDIDECASNP CRKGATCIND VNGFRCICPE GPHHPSCYSQ
VNECLSNPCI HGNCTGVANG YKCLCEAGWV GINCEVDKNE CLSNPCQNGG TCDNLVNGYR
CTCKQGFKGY NCQINIDECA SNPCLNQGTC TDDISGYTCH CMLPYTGKNC QMVLAPCNPN
PCENAAICQE SANFESYTCL CAPGWQGPRC NVDIDECVSK PCMNRGVCHN TEGSYLCKCL
PGFTGVDCEE DIDECLANPC QNGATCVDGV NSFSCLCLPG FNGDRCQTDM NECLSEPCKN
GGTCSDYVNS YTCRCQAGFD GPHCENNIDE CTESSCFNGG TCVDGTNSFS CLCPVGFTGP
FCLHEINECN SHPCLNEGTC IDGVGTYRCN CPLGYTGKNC QTLVNLCSRS PCKNKGTCIQ
RKAESQCLCP SEWTGAYCDV PNVSCEVAAS RRRVSVDRLC EHSGTCIDAG NTHHCQCPLG
YTGSYCEKQL DECASNPCQH GATCRDYVGG YRCECVPGYQ GVNCEYEVDE CQYQPCQNGG
TCIDLVNHFK CSCPPGTRGL RCEENIDDCA PDAGGPHCLN GGQCVDKIGG YTCRCLPGFA
GERCEGDINE CLSNPCNPEG SLDCIQLINN YSCICRSTFT GRHCETFVDV CPQMPCLNGG
VCAVASNTPS GFICHCPPGF SGARCQSTCG HMKCKKGEQC VHTTLGPRCF CPRPEDCETG
CASSPCQHGG SCSPQKKPPY YTCQCPPSFW GSRCEFSAGP TNSPPPACLS QHCAEKARDG
VCDEDCNSHA CQWDGGDCSL TMEDPWANCS SPLPCWDYIN HQCDELCNTA ECLFDNFECQ
GSSKTCKYDK YCADHFSDNH CDQGCNSEEC GWDGLDCATD QPENLAEGTL VIVVLLPPEQ
LLQDAHSFLR SLGTLLHTNL RIKRDAQGAL MVFPYYGEKS PANLNRKSTI NRRSLPDEQE
REVAGSRVFL EIDNRQCVQA SDQCFKNTDA AAALLASHAI QGTLSYPLVS VLSESLDPKP
TQLLYLLAVA IVIVLLVILL GVIMAKRKRK HGSLWLPEGF ILRRDSNNHT RREPVGQDAM
GLKSLSVQVS EGNLIDSSTN EHWADDGAPQ PKRSKAEDQA LLSEEGDPID RRQWTQQHLE
AADIRRTPSL ALTPPQAEQE VDVLDVNVRG PDGCTPLMLA SLRGGSSDLS EDDEEADDSS
ANIITDLVYQ GASLQAQTDR TGEMALHLAA RYSRADAAKR LLDAGADANA QDNMGRCPLH
AAVAADAQGV FQILIRNRVT DLDARMHDGT TPLILAARLA VEGMVAELIN CQADVNAVDD
HGKSALHWAA AVNNVEATLV LLKNGANRDM QDNKEETPLF LAAREGSYEA AKILLDHFAN
RDITDHMDRL PRDVARDRMH HDIVRLLNEY NVAHSPPGAM LTSALSPVIC GANRSFLNLK
HTPAGKKPRR PHAKGAVPTS LPNLAKEAKD SKGGRRKKSL SDKGQLSESS VTLSPVDSLE
SPHTYVSDTT SSPMITSPGL LQASPSPMLA PAAPVHAQHA VSFSNLHEMQ ALPHGANPVL
PSVSQLLPHH HLAPAGAGSG SGRLHPVAVQ ADWMSRMEIN ESQYNEMFGM VLAPAEGAHS
VLAPPNRPGQ PEGKHVAPSR EPLPPIMTFQ LIPKGGIAQP AGAAQPPACP PAVAGPLPTM
YQIPDMARLP SVAFPTGMMP QQDGQAVQTV LPPYHPFPSS VGKYPTPPSQ HSYASSTAAE
RTPSHSGHLQ GEHPYLTPSP ESPDQWSSSS PHSASDWSDV TTSPTPGGSG GGQRGPGAHM
AEPPPRTNMQ VYA
//