ID G3WVJ4_SARHA Unreviewed; 1907 AA.
AC G3WVJ4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Ankyrin 1 {ECO:0000313|Ensembl:ENSSHAP00000019449.2};
GN Name=ANK1 {ECO:0000313|Ensembl:ENSSHAP00000019449.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000019449.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000019449.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000019449.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 9305.ENSSHAP00000019449; -.
DR Ensembl; ENSSHAT00000019606.2; ENSSHAP00000019449.2; ENSSHAG00000016518.2.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000155760; -.
DR InParanoid; G3WVJ4; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0170014; C:ankyrin-1 complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0014731; C:spectrin-associated cytoskeleton; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0008093; F:cytoskeletal anchor activity; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08805; Death_ank1; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 147..171
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 209..241
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 242..274
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 275..307
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 308..340
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 341..373
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 374..406
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 407..439
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 440..472
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 473..505
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 506..538
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 539..571
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 572..596
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 605..637
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 638..670
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 671..703
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 704..736
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 737..769
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 925..1080
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1082..1228
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1417..1501
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 888..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1600..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1650..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1683..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1782..1802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1861..1879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1907 AA; 209473 MW; B8E816618A5ACBDA CRC64;
MAARQGRSDP DPAADAATSF LRAARSGNLD KALDHLRNGV DINTCNQNGL NGLHLASKEG
HVKMVVELLH KEIVLETTTK KGNTALHIAA LAGQDEVVRE LVNYGANVNA QSQKGFTPLY
MAAQENHLEV VKFLLENGAN QNVATEDGFT PLAVALQQGH ENVVAHLINY GTKGKVRLPA
LHIAARNDDT RTAAVLLQND PNADVLSKTG FTPLHIAAHY ENLNVAQLLL NRGASVNFTP
QNGITPLHIA SRRGNVIMVR LLLDRGAEIE TRTKDELTPL HCAARNGHVR ISELLLDHGA
PIQAKTKNGL SPIHMAAQGD HLDCVRLLLQ YNAEIDDITL DHLTPLHVAA HCGHHRVAKV
LLDKGAKPNS RALNGFTPLH IACKKNHIRV MELLLKTGAS IDAVTESGLT PLHVASFMGH
LPIVKNLLQR GASPNVSNVK VETPLHMAAR AGHTEVAKYL LQNKAKVNAK AKDDQTPLHC
AARIGHTDMV KLLLENNANP NLATTAGHTP LHITAREGHM ETARALLEKE ASQACMTKKG
FTPLHVAAKY GKVNVAELLL ERDAHPNAAG KNGLTPLHVA VHHNNLEIVK LLLPRGGSPH
SPAWNGYTPL HIAAKQNQME LASNLLQYGG SANAESVQGV TPLHLAAQEG HAEMVALLLS
KQANGNLGNK SGLTPLHLVA QEGHVAVADV LIKQGVTVDA TTRMGYTPLH VASHYGNIKL
VKFLLQHQAD VNAKTKLGYT PLHQAAQQGH TDIVTLLLKN SASPNEVSSN GTTPLAIAKR
LGYISVTDVL KIVTDETGVV LVSDKHRMSF PERVDENLDV SEDEGTAHVT IMGEELMGPK
PEKQDSRDVD EEKELLDFVP KLDQVVESPA IPRIPCVTPE TVVIRAEEPE QASKEFDEDS
LIPSSPATET SDNISPVASP VHTGFLVSFM VDARGGSMRG SRHNGLRVII PPRACAAPTR
ITCRLVKPQK LTTPPPLAEE EGLASRIIAL GPTGGQFLSP VIVEIPHFAS HGRGDRELVV
LRSENGSMWK EHRSRYGESY LDQALNGMDE ELESLEELEK KRVCRIITTD FPLYFVVMSR
LCQDFDMIGP EGGSLKSKLV PMVQATFPET AVTKKVKLAL QAQPVPDELV TKLLGNQATF
SPIVTVEPRR RKFHRPIGLR IPLPPSWKDN PRDSGEGDTT SLRLLCSVIG GIAQAQWEDI
TGTTKLVYAN ECANFTTNVS ARFWLSDCPR TAEAVDFATL LYKELTAVPY MAKFVVFAKM
NDTREGRLRC YCMTDDKVDK TLEQHENFVE VARSRDIEVL EGMPLFAELS GNLVPVKKAA
QQRSFHFQSF RENRLAISVK VRDSSREAGG SLSFLRKAMK YEDSQHILCH LNITMPPCTK
GSGADDRRRT LTPLALRERY SLLSETTLGS LSGTDRADMK MAIISEHLGL SWAELARELQ
FGVEDINRIR VENPNSLLEQ SSALLNLWVI REGKNAKMEN LYTALRNIDR SEIVNMLEGS
GRQSRSLKPD RRYADRDYSL SPSQMNGYTS LQDELLSPAS LHYTLPSPLR VDQYWTEVAI
IDAIPMAPTE HDALMEMSDM QVWSSGLTPS LVTAEDSSLE CSKAEDSDAT GEWRLPGPLL
EDPQGPDQLG SLELVEDDTV DSDATNGLID LLDQEEGQRS EEKLPGGERQ DEPAGQGRDS
EREVSLLSGQ QRVQARITES PTVSRVMEKS QDRTKDWDTD GSITSYLKDA AQSSWQEEVT
GGPHSIQRTI TTISSVKSLE PSGSQEYEKI LMPTVEHMRI DSLEQSESES PLTEREHRHP
PVLSQGYGKW MEETESAFSR LVKENELQDI PGEHVTEEQF TDEQGNIVTK KIIRKVVRQI
DTSGDRDTQE LEEAEEVRGS STLQSELIEG RKGAQIVKRA SLKRGKQ
//
