ID G3WVV9_SARHA Unreviewed; 1135 AA.
AC G3WVV9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Platelet endothelial aggregation receptor 1 {ECO:0000313|Ensembl:ENSSHAP00000019564.2};
GN Name=PEAR1 {ECO:0000313|Ensembl:ENSSHAP00000019564.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000019564.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000019564.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000019564.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3WVV9; -.
DR STRING; 9305.ENSSHAP00000019564; -.
DR Ensembl; ENSSHAT00000019721.2; ENSSHAP00000019564.2; ENSSHAG00000016614.2.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000154225; -.
DR HOGENOM; CLU_008281_1_0_1; -.
DR InParanoid; G3WVV9; -.
DR TreeFam; TF332598; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl.
DR GO; GO:0043654; P:recognition of apoptotic cell; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF12; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00180; EGF_Lam; 13.
DR PROSITE; PS00022; EGF_1; 11.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1135
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029861906"
FT TRANSMEM 757..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..105
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 227..261
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 274..304
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 487..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 578..608
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 616..650
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 658..693
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 932..1135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1040..1071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1104
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 251..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 294..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 512..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 598..607
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 683..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1135 AA; 120909 MW; 0879B4B703594435 CRC64;
MLSRTLPPLS VLFLLLPGLG STLNSNDPNV CSYWESFTTT MKESYSHPYT QPPTEPCNQL
WGHDRSCPQP KIVYRTAYRQ AVKVNHRRRL RCCQGYYESS GACVPLCSQE CVHGRCIAPN
QCQCENGWRG DDCSSSCPLQ LWGKNCENVC ECGNNSTCDP KTGACVCPPG FQPPRCFQRC
PPGFYGPDCL AQCHCHGASC DFQTGACDCP ANSTGPSCEI SCHLDTVDFS CPRSHPCQNG
GIYNSDQNCT CPPGWMGSIC SLPCPEGRYG RGCTQECHCH NGGQCDPILG HCHCAPGYTG
DRCREECPVN RFGQDCAETC DCAPGARCYA VDGACLCEDG FTGDRCAERL CPDGSYGLAC
EASCTCHPEH SLSCHPMSGE CSCRPGWAGL HCNESCPPGT HGPGCREPCL CLHGGTCQAE
SGNCLCPPGY TGPHCSNLCP LDTFGVNCSQ SCSCVHALTC SPVDGTCNCK EGWQKGNCSV
PCPEGTWGFG CNASCQCAHG AACSPQTGAC SCTPGWRGDR CQLPCLKGQF GPGCASHCDC
KHADGCDPIH GHCQCRPGWT GLHCDLPCPE GFWGPHCNNS CTCKNGGTCI PENGSCICVP
GYRGPSCQRT CQPGRYGKRC APCKCANHSS CNPIDGSCHC HAGWTGPDCS QPCPLGYWGN
NCAHLCQCHN NGRCQPQEGT CICPPGWTGH LCSEGCPPGM FGANCSHLCQ CGPEGQCHAE
TGACICPPGH SGAPCKIGNA DQPFTMVPTL PVTYDSLGAV IGIAVLGALV VALVALFIGY
RHWQKGKAHQ HLAVAYSSGR LDGSEYVIPD IPPSYSHYYS NPSYHTLSQC SPTPPPPNKV
PGTQLFASLQ APDRPGAYGQ DIHATLPADW KHHKEFPPGH WERGRSLLDR YSYSSGNGVG
HLYGKGPIPE EGMGASRSSL CSENPYATIR DLPSLLGPHG EGSYMEMKGS PGAAAEALRE
PSPPRRQAPQ PRRSQRLRRP DSQRDSGTYE QPNPPAPGER DPVPSRAEAE SDGDGGGGGG
GGESPKGNGT GVSYPDGLAG DREGEQRGRE GRGKRERMKE TDQEEAPDWG LGHRTLTHSA
LLPSPDSASR GAQPPVPPGL PPGHYDSPKN SHIPGHYDLP PVRHPPSPPR LRQDR
//