ID G3WWS2_SARHA Unreviewed; 1242 AA.
AC G3WWS2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX38 {ECO:0000313|Ensembl:ENSSHAP00000019877.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000019877.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000019877.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000019877.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC PRP16 sub-subfamily. {ECO:0000256|ARBA:ARBA00038040}.
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DR AlphaFoldDB; G3WWS2; -.
DR STRING; 9305.ENSSHAP00000019877; -.
DR Ensembl; ENSSHAT00000020034.2; ENSSHAP00000019877.2; ENSSHAG00000016871.2.
DR eggNOG; KOG0924; Eukaryota.
DR GeneTree; ENSGT00940000156898; -.
DR HOGENOM; CLU_001832_6_2_1; -.
DR InParanoid; G3WWS2; -.
DR TreeFam; TF105793; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:Ensembl.
DR CDD; cd17983; DEXHc_DHX38; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF91; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 557..720
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 742..917
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1170..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 142388 MW; 4608FAA66DCD9B5A CRC64;
MPAFEREFPK PVMEDTSEDG EASIHRLEGI DQETQVGGLI CKTKSASSEQ HVFKAPAPRP
SLLGLDLLAA LKRREREEKD DGEDKKKSRV SSYKDWEESK DDQKDSEEER SDQASRSSRK
DRHYRAARVE TPSHPGGVSE EFWERSRQRE RERREHGVYA SSKEEKDRKK ERTRDRDYDR
KRDRDERDRS RHSSRSDRDG GSERSSRRNE PESPRHRPRD AATPSRSNWE EEDSAYGSSR
RSQWESPSPV LSYRDSERSH RTSSTRDKER SVRSKCPDDT PLPTPSYKYN EWADDRRHLG
STPRLSRGRG RREDGEDGIS FDTEEERQQW EDDQRQADRD WYMMDEGYDE FHNPLAYSSE
DYVKKREQHL HKQKQKRISA QRRQINEDNE RWETNRMLTS GVVHRLEVDE DFEEDNAAKV
HLLVHNLVPP FLDGRIVFTK QPEPVIPVKD ATSDLAIIAR KGSQTVRKHR EQKERKKAQH
KHWELAGTKL GDIMGLKKEE EPEKPLTEDG KVDYRTEQKF ANHMKKKSEA SSEFAKKKSI
LEQRQYLPIF AVQQELLTIV RDNSIVIVVG ETGSGKTTQL TQYLHEDGYT DYGMIGCTQP
RRVAAMSVAK RVSEEMGGSL GEEVGYAIRF EDCTSENTVI KYMTDGILLR ESLREADLDH
YSAIIMDEAH ERSLNTDVLF GLLREVVARR SDLKLIVTSA TMDAEKFAAF FGNVPIFHIP
GRTFPVDILF SKTPQEDYVE AAVKQSLQVH LSGAPGDILI FMPGQEDIEV TSDQIVEHLE
ELENAPALAV LPIYSQLPSD LQAKIFQKAP DGVRKCIVAT NIAETSLTVD GIMFVIDSGY
CKLKVFNPRI GMDALQIYPI SQANANQRSG RAGRTGPGQC FRLYTQSAYK NELLTTTVPE
IQRTNLANVV LLLKSLGVQD LLQFHFMDPP PEDNMLNSMY QLWILGAMDN TGGLTSTGRL
MVEFPLDPAL SKMLIVSCDM GCSSEILLIV SMLSVPAIFY RPKGREEESD QIREKFAVPE
SDHLTYLNVY LQWKNNNYST LWCNEHFIHA KAMRKVREVR AQLKDIMVQQ RMSLASCGTD
WDIVRKCVCA AYFHQAAKLK GIGEYVNIRT GMPCHLHPTS SLFGMGYTPD YIVYHELVMT
TKEYMQCVTA VDGEWLAELG PMFYSIKHAG KSRQENRRRA KEEASAMEEE MALAEEQLRA
RRQEQEKRNP LGSVRSVKIY TPGRKEQGEP ASPRRTPARF GL
//
