ID G3WX37_SARHA Unreviewed; 471 AA.
AC G3WX37;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=RasGEF domain family member 1C {ECO:0008006|Google:ProtNLM};
GN Name=RASGEF1C {ECO:0000313|Ensembl:ENSSHAP00000019992.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000019992.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000019992.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000019992.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003756934.1; XM_003756886.1.
DR AlphaFoldDB; G3WX37; -.
DR STRING; 9305.ENSSHAP00000019992; -.
DR Ensembl; ENSSHAT00000020150.2; ENSSHAP00000019992.2; ENSSHAG00000016960.2.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000160245; -.
DR TreeFam; TF313379; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF186; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 32..162
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 203..451
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 471 AA; 54039 MW; DD44D4ED8C839A76 CRC64;
MPQTLSATSM VTPCGFSPHL HSSGEQGGLI FQDGNLSSAS LDALIQHLIP TTDYYPEKAY
IFTFLLSSRL FIEPHELLAR VCHQCIEQQR LDEPVLDKAR VRKFGPKLLQ LLAEWTETFP
YDFQEEKMVG HLKDMIRRIA PCDEAYWKRM NQLLQALNQK LATLSHGQEG LVKISPTVSD
KLVSFKTKPP PSIQREILSV CSDPYTLAQQ LTHVELERLS HIGPEEFVQA FVHKDSLDST
KSCFSEQNKT NNLEAYVKWF NRLCYLVATE ICMPAKKKQR AQVIEFFIDV ARECFNIGNF
NSLMAIISGM NMSPVSRLKK TWSKVKTAKF FILEHQMDPT GNFYNYRTAL RGAAHRSLTA
HSNREKIVIP FFSLLIKDIY FLNEGCANRL PNGHVNFEKF LELAKQVGEF ITWKQVECPF
EQDPNITHYL HTAPIFTEDG LYLASYESES PENQVEKERW KSLRSTILGK T
//
