ID G3WXT0_SARHA Unreviewed; 368 AA.
AC G3WXT0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase 46 {ECO:0000256|ARBA:ARBA00039415};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
DE AltName: Full=Deubiquitinating enzyme 46 {ECO:0000256|ARBA:ARBA00042431};
DE AltName: Full=Ubiquitin thioesterase 46 {ECO:0000256|ARBA:ARBA00041292};
DE AltName: Full=Ubiquitin-specific-processing protease 46 {ECO:0000256|ARBA:ARBA00042999};
GN Name=USP46 {ECO:0000313|Ensembl:ENSSHAP00000020235.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020235.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020235.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020235.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP12/USP46 subfamily.
CC {ECO:0000256|ARBA:ARBA00038282}.
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DR AlphaFoldDB; G3WXT0; -.
DR STRING; 9305.ENSSHAP00000020235; -.
DR Ensembl; ENSSHAT00000020395.2; ENSSHAP00000020235.1; ENSSHAG00000023109.1.
DR eggNOG; KOG1864; Eukaryota.
DR GeneTree; ENSGT00940000153284; -.
DR HOGENOM; CLU_008279_2_0_1; -.
DR OMA; ANFGNTC; -.
DR TreeFam; TF314144; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR CDD; cd02663; Peptidase_C19G; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF714; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Behavior {ECO:0000256|ARBA:ARBA00022610};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 37..367
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 368 AA; 42757 MW; 3BF6D016F82B1CD4 CRC64;
MISWFCSFHS ASVHGTNASA LEKDIGPEQF PINEHYFGLV NFGNTCYCNS VLQALYFCRP
FRENVLAYKA QQKKKENLLT CLADLFHSIA TQKKKVGVIP PKKFISRLRK ENDLFDNYMQ
QDAHEFLNYL LNTIADILQE EKKQEKQNGK LKNGNMNEPV ENNKPELTWV HEIFQGTLTN
ETRCLNCETV SSKDEDFLDL SVDVEQNTSI THCLRDFSNT ETLCSEQKYY CETCCSKQEA
QKRMRVKKLP MILALHLKRF KYMEQLHRYT KLSYRVVFPL ELRLFNTSSD AVNLDRMYDL
VAVVVHCGSG PNRGHYITIV KSHGFWLLFD DDIVEKIDAQ AIEEFYGLTS DISKNSESGY
ILFYQSRE
//
