ID G3WY28_SARHA Unreviewed; 855 AA.
AC G3WY28;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=ADAM metallopeptidase domain 23 {ECO:0000313|Ensembl:ENSSHAP00000020333.2};
GN Name=ADAM23 {ECO:0000313|Ensembl:ENSSHAP00000020333.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020333.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020333.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020333.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3WY28; -.
DR STRING; 9305.ENSSHAP00000020333; -.
DR Ensembl; ENSSHAT00000020494.2; ENSSHAP00000020333.2; ENSSHAG00000017245.2.
DR eggNOG; KOG3607; Eukaryota.
DR GeneTree; ENSGT00940000158781; -.
DR HOGENOM; CLU_012714_6_1_1; -.
DR InParanoid; G3WY28; -.
DR TreeFam; TF314733; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF13; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 306..502
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 508..594
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 738..775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 566..586
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 765..774
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 855 AA; 95667 MW; F38263E006CC359E CRC64;
MKPPGISALR QPSPGCSLFA AASSSSFGTT ATSFPSCWQS PPLLLHTLCR LRLLLLLQLL
SGSFWSQPWG AAAASASYWN ETAKETTGVL ADEENAFQQN SSRRNNNSYS SAVQKEITLP
SRLVYYINQD SESPYHVLDT KARHQQKHNK AVHLAQASFQ IEAFGSRFIL DLTLNNGLLS
SNYVEIHYED GKPQYSKGGE HCYYHGNIRG IKDSKAALST CNGLHGMFED NTFMYMIEPL
ELIHNTKSTG RPHIIQRTLG GHTSKQLKNL SMEEHDQWPF LSELQWLKKR RRKRRAAPRG
VFEEMKYLEL MIVNDHKMYK KYRSHAHTNN FAKSVVNLVD SIYKEQLNTR VVLVAVETWT
EKDYIDIRSD PVQMLHEFSK YRQRIKQHAD AVHLISRVIF HFKRSSLSYF GGVCSKTRGV
GVNEYGLPMA VAQGLSQSLA QNLGIQWEPS SRKPKCDCTE SWGGCIMEET GVSHSRKFSK
CSILEYKDFL QRGGGFCLFN RPTKLFEATE CGNGYVEAGE ECDCGFHVEC YGVCCKKCSL
SNGAHCSDGP CCNSTTCLFQ PRGYNCREGV NDCDITETCT GDSGQCPPNL HKQDGYSCNS
NQGRCYNGEC KTRDNQCQFI WGSKAAGSDK FCYEKLNTEG TEKGNCGKDG DRWIQCSKHD
VFCGFLLCTN LTRVPRIGQL QGEIIPTSFY HQGRVIDCSG AHVVLDDDTD VGYVEDGTPC
GPSMMCLDRK CLQIQSLNMS SCPLDSNGKV CSNHGVCSNE VTCICNNTWA GTDCSIRDLI
KKPPASKDDG PKGTPWVPVI DWERSPPALS SPHTLFTPFH CQFLYNLNYI LGGSSKIKLE
FKLNSEESFR SSDPL
//
