ID G3WY53_SARHA Unreviewed; 259 AA.
AC G3WY53;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cerberus 1, DAN family BMP antagonist {ECO:0000313|Ensembl:ENSSHAP00000020358.1};
GN Name=CER1 {ECO:0000313|Ensembl:ENSSHAP00000020358.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020358.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020358.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020358.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR027807}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872,
CC ECO:0000256|PIRNR:PIRNR027807}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR RefSeq; XP_003762198.1; XM_003762150.1.
DR AlphaFoldDB; G3WY53; -.
DR STRING; 9305.ENSSHAP00000020358; -.
DR Ensembl; ENSSHAT00000020519.2; ENSSHAP00000020358.1; ENSSHAG00000017268.2.
DR GeneID; 100935288; -.
DR KEGG; shr:100935288; -.
DR CTD; 9350; -.
DR eggNOG; ENOG502S2G4; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_104447_0_0_1; -.
DR InParanoid; G3WY53; -.
DR OMA; FCSHCSP; -.
DR OrthoDB; 5347549at2759; -.
DR TreeFam; TF106445; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0016015; F:morphogen activity; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR GO; GO:0032926; P:negative regulation of activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:2000381; P:negative regulation of mesoderm development; IEA:Ensembl.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IEA:Ensembl.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273:SF4; CERBERUS; 1.
DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Secreted {ECO:0000256|PIRNR:PIRNR027807};
KW Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT CHAIN 18..259
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT /id="PRO_5024527631"
FT DOMAIN 163..248
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
SQ SEQUENCE 259 AA; 29951 MW; 48EC3B41B095F877 CRC64;
MYLLLLQLLV ISGLGESRQQ MLQDRKKRSQ RSSHALSDRS LVALSADVSE EAQEKPDLFV
AIPHLIDPEL TEAPREQREM LFRFMFTSEK QKPERHLEIR DPAREAFKPR TPANAESDGR
EIEKSHLQEE AQKFWHYFLF RKSSASQEVI LPIKSNEVYQ ETCRTVPFSQ TILHDDCEKV
VIQNNLCFGK CRSHRLSEAT THHHAFCSHC SPTKFTTKEL LLNCTGLNPV VKVVMIVEEC
QCKIKQDQDE AHLHFDSHA
//
