ID G3WYT9_SARHA Unreviewed; 376 AA.
AC G3WYT9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Lysophosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00015438};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=2-arachidonoylglycerol hydrolase ABHD12 {ECO:0000256|ARBA:ARBA00033386};
DE AltName: Full=Abhydrolase domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032497};
DE AltName: Full=Monoacylglycerol lipase ABHD12 {ECO:0000256|ARBA:ARBA00030575};
DE AltName: Full=Oxidized phosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00030502};
GN Name=ABHD12 {ECO:0000313|Ensembl:ENSSHAP00000020594.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000020594.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000020594.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000020594.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the serine esterase family.
CC {ECO:0000256|ARBA:ARBA00006584}.
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DR AlphaFoldDB; G3WYT9; -.
DR STRING; 9305.ENSSHAP00000020594; -.
DR ESTHER; sarha-g3wyt9; ABHD12-PHARC.
DR Ensembl; ENSSHAT00000020759.2; ENSSHAP00000020594.2; ENSSHAG00000017466.2.
DR eggNOG; KOG1552; Eukaryota.
DR GeneTree; ENSGT00940000160517; -.
DR HOGENOM; CLU_029375_1_0_1; -.
DR OrthoDB; 47056at2759; -.
DR TreeFam; TF315122; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047372; F:acylglycerol lipase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF61; LYSOPHOSPHATIDYLSERINE LIPASE ABHD12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..249
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 376 AA; 43739 MW; 73344919E8B0D0A9 CRC64;
MFWWCGCLGA CADTCLFVSS MKVCRFFFPV PLKRSWTWRR KGLWFRLRKI LLWLLALYIA
IPFLVKLCPG IQAKLIFLNF VRVPYFIDLK KPQEQGLNHT YNYYLQPEEG VTIGVWHTVP
AVLWKNAQGK DQVWYEDTLA SNHPIILYLH GNAGTRGGDH RVALYKVLSS LGYHVVTFDY
RGWGDSIGTP TEGGMTYDAL HVFDWIKARS GYNPVYIWGH SLGTGVATNL VRRLCERETP
PDALILESPF TNIREEAKSH PFSVVYRYFP GFDWFFLDPI TSSGIKFAND ENVKYISCSL
LILHAEDDPI VPFHLGRKLY NIAAPSQSFR DFKVQFIPFH RDLGYRHKYI YKSPELPRIL
REFLGKSEHE HHELRH
//
