ID G3X040_SARHA Unreviewed; 980 AA.
AC G3X040;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Ubiquitin like modifier activating enzyme 7 {ECO:0000313|Ensembl:ENSSHAP00000021045.2};
GN Name=UBA7 {ECO:0000313|Ensembl:ENSSHAP00000021045.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021045.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021045.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021045.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673, ECO:0000256|RuleBase:RU000519}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3X040; -.
DR STRING; 9305.ENSSHAP00000021045; -.
DR Ensembl; ENSSHAT00000021215.2; ENSSHAP00000021045.2; ENSSHAG00000017846.2.
DR eggNOG; KOG2012; Eukaryota.
DR GeneTree; ENSGT00940000161447; -.
DR HOGENOM; CLU_002556_0_0_1; -.
DR OrthoDB; 20494at2759; -.
DR TreeFam; TF300586; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01491; Ube1_repeat1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR033127; UBQ-activ_enz_E1_Cys_AS.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF143; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 7; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
DR PROSITE; PS00865; UBIQUITIN_ACTIVAT_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU000519};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000519};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU000519};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU000519}.
FT DOMAIN 882..980
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
FT ACT_SITE 599
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10132"
SQ SEQUENCE 980 AA; 109140 MW; 31C2063834059BA3 CRC64;
MGDLKTCLDV NEQLYSRQLY VLGRNAMRRL RGSSMLVSGM KGLGVEIAKN LVLAGVGNLA
LHDPRPTCWA DLASQFFLSE KDIGRKRAEA SLAPLAQLNS DVRITTHDGP LTEAVLRGFQ
VVVLTDSTLE EQLQVGSLCH EHGVRFLVAS TRGLVGQLFC DFGEKFTVYN PWEAEPLENN
ICHIHHISQG SPGILTVLEE AGHNFQHGAW VTFSGIEGMT ELNDCDPQPI RALDRWTLEI
GDTTAFSPYL QNGVVTEVRK PQTYSYEALS LSLEHPRIVA ASDQEAQRAC CLHRAFQALH
KYQAQTGRLP RPWHLEDANK LVVLAQGLEP LQGDNGRKPN EPLDEALVRK FAMTSTGDLS
PINSFLGGMA AQEMLKAASG KFQPLNQWLY FDALECLPED GKFYLTPEAC APRDCRYDGQ
IAVFGDDFQK KLGKQRYFLV GAGAIGCELL KIFAMLGLGA GEGGGITVTD MDTVELSNLN
RQFLFRSQDL QKSKSEAAAL AVRSMNPALS VTTHTSELGP DTEHLFGDDF FSSLDGVASA
VDSFQARNYV SKRCVHYLKP MLESGTQGTQ GSASIFVPFL TEPYRVIAED APETAYPLCT
LRSFPSTIEH TLQWARNEFE GLFRLTAETI NRYLQEPGFL KETGAPQVLD HLKTASTSFL
TPPQCWRDCV AWARGRWQHC FHDSITHLLQ YFPPDKVSEE GVPFWSGTKL CPRPLEFDIG
GDTHLDYVLA AANLYAQTHK LPGSQDRDQV CAILRDLPTP AFQGQAHGPV FADDQELSQA
SARWDPTHLQ ELCSTLEKWR GTPLEPQLFE KDDDSNFHVD FIVAASNLRA NNYGIPPADR
NKSKKIVGKI IPAIATTTAV VAGLVGLELY KVVMGHQRLS SYRHSRLQLA TPHLFRWIPK
EPCVQKYRDM SWTSWDRLTV PAPAPGQPEM TLKGLLTYLQ EKHGLPVTML LLLDSPHCLY
SRRWPEAQQN LQLRYTGFRS
//
