ID G3X1F5_SARHA Unreviewed; 897 AA.
AC G3X1F5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Nuclear factor of activated T cells 2 {ECO:0000313|Ensembl:ENSSHAP00000021510.2};
GN Name=NFATC2 {ECO:0000313|Ensembl:ENSSHAP00000021510.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021510.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021510.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021510.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3X1F5; -.
DR STRING; 9305.ENSSHAP00000021510; -.
DR Ensembl; ENSSHAT00000021684.2; ENSSHAP00000021510.2; ENSSHAG00000018222.2.
DR eggNOG; ENOG502QTJI; Eukaryota.
DR GeneTree; ENSGT00940000156230; -.
DR HOGENOM; CLU_010185_1_1_1; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF4; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 2; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 366..548
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 205..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 99042 MW; B53B61E9EAFE5ED5 CRC64;
MQRETAYRLV HFHHHHIMRS MDQEEPTPHN IVSPPSGCPD DVLDYGLKPY TPPPSNSADP
MGKYGQPDSI GSKCYLDPAK PVGPSALSPR IEITPSELSG GSFRIRDTDL LVEHQPNSAT
ASPRFTLPVP GFEGYRDPPC LSPASSGSSA SFISETNFSP YTSPCVSPNN GPSDDLCPQL
QNIHTHYSPR TSPIMSPRTS ITEETYLGRH SPSPRPNSRS SSPGAKRRYS CAELFTTQLP
SASPHQSRTP SPQALPNVSL REDGPSVTCT QLPNSTILMD TMSNLTTDPP CGIPSKMWKT
SPDPSPVPSQ KPSVPRHSIY PNVDYLGSCE QEERRNSAPE SILLVPPTWP KQLVPAIPIC
SIPVTASLPP LEWPLSNQSG SYELRIEVQP KPHHRAHYET EGSRGAVKAP TGGHPVVQLH
GYMENKPLGL QIFIGTADER ILKPHAFYQV HRITGKTVTT TSYEKIVGNT KVLEIPLEPK
NNMKATIDCA GILKLRNADI ELRKGETDIG RKNTRVRLVF RVHIPESSGR IVSLQAASNP
IECSQRSAHE LPMVERQDID SCLVYGGQQM ILTGQNFTAE SKVVFTEKTT DGQQIWEMEA
TVDKDKSQPS MLFVEIPEYR NKHIRTPVKV NFYVINGKRK RSQPQHFTYH PVPSIKTEPI
DEYDPALICN TVHSALGTVT QPYYSQHTMV TESPSCLVAT MASCQQFRSG LSSPDSRYQQ
QNSTAVIYQR SKSLSPSLLG YQQPTLMASS ISISDAHRSV LMHAGSPGQN SALLHHSPTN
QQSSPVIHYS PTNQQVRCGT HQEFQHIMCC ENFTSSAARP NPPQVSQAQR ISPSSYPTVI
QQQNATTQRA AKNGPPVNDQ KEVLPAGVTI KQEQNLDQAY LDDELIDTHL SWIQNII
//
