ID G3X2S5_SARHA Unreviewed; 1023 AA.
AC G3X2S5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Integrin subunit alpha 10 {ECO:0000313|Ensembl:ENSSHAP00000021980.2};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSSHAP00000021980.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000021980.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000021980.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000021980.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; G3X2S5; -.
DR STRING; 9305.ENSSHAP00000021980; -.
DR Ensembl; ENSSHAT00000022156.2; ENSSHAP00000021980.2; ENSSHAG00000018604.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000158423; -.
DR HOGENOM; CLU_004111_2_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 980..1002
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 24..207
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 329..391
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 392..450
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 454..514
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1023 AA; 112399 MW; 25E5887ED64AC3EE CRC64;
MELSLSPHLP LPVLLLAGCP TYMDVVIVLD GSNSIYPWAE VQTFLRRLVG RLFIDPEQIQ
VGLVQYGETA VHEWSLGDFR TKEEVVKAAR NLSRREGRET HTAQAIMVAC TEGFSPSRGG
RPEAARLLVV VTDGESHDGE ELPAALRACE AGSVTRYGIA VLGHYIRRQR DPSSFLREIR
AIASDPDERF FFNVTDEAAL TDIVDALGDR IFGLEGSHGE NESSFGLEMS QIGFSTHQLK
DGILFGMVGA YDWGGSVLWL KEGHRLFPPR TALEEEFPTA LQNHAAYLGY SVSSLILLGG
RRLFLSGAPR FKHRGKVIAF QLRKDGSMNV AQSLQGEQIG SYFGSELCPL DTNGDGVTDV
LLVAAPMYLG PQYRETGRVY VYLVGQQPSL ILWRTLQPDP PQDSRFGFAM AALPDLNQDG
FADVAVGAPL EDGHRGALYI YHGTQGGIRP HPAQRISAAS MPQPLSYFGR SVDGQLDLDG
DELVDVAVGA QGAAVLLSSR PIVHLAPSLT VTPPAVSVVQ RDCQRHGQDA TCLTADLCFQ
VTSRTPGRWN RRFYVRFSAS LDEWTAGARA AFDGFGQRLP VRRLRVSVGN VTCQQLHFHV
LDASDYLRPL ALAVTFELDN ATKPRPVLDE DSPTSLRKLV PFSKDCGPDN ECHTDLVLQV
DMDIRGSRKK PFVVRGGRQK VLVSATLENR KENAYNTNLS LSFSRSLHLA SFTPQKDPSV
KVECTATSTH GQLCSIGHPV FQTGAKVTFV LEFEFSCSSL LSQALVRLAA TSNSLESNET
LHDNVVQASA YIRYEPEILV SSESTLHRYE VHPYGALPEG PGPEFKTTLR VQNLGCYSIS
DLLISAFFPA VAYGGSYFLS LSQIIADNAS CMVQNLTEPS EAPVHSEDLR HVSRLNGSNS
RCQVVRCHLG RLPRGSQSSL QFLRLIHDDF FRRAKFKSVT VVSTFKLGVE EGSILQLMEA
SQWSESLLEV IQARHVPVSL WILVGSVIGG LLLLALIVFC LWKLGFFARK KAPEEDGNGK
VDQ
//
