ID G3X3N7_SARHA Unreviewed; 717 AA.
AC G3X3N7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=KRIT1 ankyrin repeat containing {ECO:0000313|Ensembl:ENSSHAP00000022292.2};
GN Name=KRIT1 {ECO:0000313|Ensembl:ENSSHAP00000022292.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000022292.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000022292.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000022292.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3X3N7; -.
DR STRING; 9305.ENSSHAP00000022292; -.
DR Ensembl; ENSSHAT00000022470.2; ENSSHAP00000022292.2; ENSSHAG00000018866.2.
DR eggNOG; KOG4335; Eukaryota.
DR GeneTree; ENSGT00530000063721; -.
DR HOGENOM; CLU_022188_0_0_1; -.
DR OrthoDB; 2876335at2759; -.
DR TreeFam; TF317921; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.70.2240; KRIT, N-terminal Nudix domain, NPxY motif-rich region; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032022; NUDIX.
DR InterPro; IPR043058; NUDIX_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13283; KREV INTERACTION TRAPPED 1-RELATED; 1.
DR PANTHER; PTHR13283:SF11; KREV INTERACTION TRAPPED PROTEIN 1; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF16705; NUDIX_5; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT REPEAT 354..377
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 420..717
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
SQ SEQUENCE 717 AA; 82292 MW; 000AA6F181350F96 CRC64;
MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLLEV PIEGQKKKRK KVLLETKLQG
SSEITQSILD YVVETTKPIS PANQGIKGKR VVLMKKFPLD GEKVGREASL FIVPSVVKDN
TKYSYSPGCP VFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP
SPLERIKTNV INPAYATEPS QIENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY
TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKEHQWVDDF PLHRSACEGD
SELLNRLLND SFSVNQLDND HWAPIHYACW YGKVEATRML LEKGKCNPNL LNGQLSSPLH
FAAGGGHVEI VQILLNHPEV DRHIIDQQGR SPLNVCEENK QNDWEETAKL LKEAINKPYE
KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSHETQQY FTIWICSENL SLQLKPYHKP
LQHVRDWPEI LNELTNLDPQ RETPQLFLRR DVRLPLEVEK KIEDPLAILI LFDEARYNLL
KGFYTSPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPITKL KSKAPHWTNR
ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EVPTYGAAFF TGQVFTKASS SSHKVIRVYV
GVNIKGLHLL NMETKTLLIS LKYGCFMWQL GDADTCFQIH SLENKMSFIV HTKQVLS
//
