ID   G3X3P4_SARHA            Unreviewed;       785 AA.
AC   G3X3P4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   Name=HECTD2 {ECO:0000313|Ensembl:ENSSHAP00000022299.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000022299.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000022299.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000022299.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_003755324.1; XM_003755276.1.
DR   AlphaFoldDB; G3X3P4; -.
DR   STRING; 9305.ENSSHAP00000022299; -.
DR   Ensembl; ENSSHAT00000022477.2; ENSSHAP00000022299.2; ENSSHAG00000018873.2.
DR   eggNOG; KOG0941; Eukaryota.
DR   GeneTree; ENSGT00940000157750; -.
DR   HOGENOM; CLU_002173_5_0_1; -.
DR   InParanoid; G3X3P4; -.
DR   TreeFam; TF315189; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          446..785
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        753
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   785 AA;  89563 MW;  942DD0BADAB0C1F5 CRC64;
     MNEDTRDPSP PAAGAAAAAA VEEKEKKDEE AEKGKEEERE KLPPVLGTSS TGASGAVERG
     AKGQLSTFSS FISTVSQKKD VAGKRSSPTQ LVTPNVKNVR DLPPICLDVR QKQRLSIDSL
     STEMKASIPP EPVLPIRTKT MKDFQEDVEK VKSSGEWKEV HDFYLTTFDS FLELSATFKK
     DANTPFNTIE DSGINAKFVN AVYDALLNTP QDIQKSVLKG TINSLLREWK GPRSKDDLRA
     YFILLQNPQF NNTSTYVIYA HLLRQIATLV EADHHFLVHW FKKLSQKRFK QLVDRLLQFI
     SLRLFPAKPE EFPPMTKCSW WIPSAAKVLA LLNTANDLAH LPLIPYTDFY NSTLDHIDLM
     EEYHTWQCFG NSRRFSFCQY PFVISIAAKK IIIQRDSEQQ MISIARQSLV DKVSRRQRPD
     MNMLFLNMKV RRTHLVSDSL DELTRKRGDL KKKLKVTFVG EAGLDMGGLT KEWFLLLIRQ
     IFHPDYGMFA YHKDSLCHWF SSYKCDNYSE FRLVGILMGL AVYNSITLDI RFPPCCYKKL
     LSPPIVPSDQ NTPVGICSVT IDDLYQIMPE LAHGLTELLS YDGNVEEDFY STFQVFQEEF
     GVIKSYNLKP SGDKIPVTNQ NRKEYVQLYV DFLLNKSIYK QFAAFYYGFH SVCASNALML
     LRPEEVEILV CGSPELDMHA LQRNTQYDGY VKTDLTIRYF WDVVLGFPLD LQKKLLHFTT
     GSDRVPVGGM ADLNFKISKH DTSTNWLPVA HTCFNQLCLP PYKNKKELKQ KLIIGISNSE
     GFGLE
//