ID G3X7E9_BOVIN Unreviewed; 424 AA.
AC G3X7E9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Interleukin 13 receptor subunit alpha 1 {ECO:0000313|Ensembl:ENSBTAP00000025754.6};
GN Name=IL13RA1 {ECO:0000313|Ensembl:ENSBTAP00000025754.6,
GN ECO:0000313|VGNC:VGNC:55053};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000025754.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000025754.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025754.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000025754.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025754.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; NP_001193606.1; NM_001206677.1.
DR RefSeq; XP_010819638.1; XM_010821336.1.
DR AlphaFoldDB; G3X7E9; -.
DR SMR; G3X7E9; -.
DR STRING; 9913.ENSBTAP00000025754; -.
DR PaxDb; 9913-ENSBTAP00000025754; -.
DR Ensembl; ENSBTAT00000025754.6; ENSBTAP00000025754.6; ENSBTAG00000019338.6.
DR GeneID; 407110; -.
DR KEGG; bta:407110; -.
DR CTD; 3597; -.
DR VEuPathDB; HostDB:ENSBTAG00000019338; -.
DR VGNC; VGNC:55053; IL13RA1.
DR eggNOG; ENOG502RYXH; Eukaryota.
DR GeneTree; ENSGT00940000160896; -.
DR HOGENOM; CLU_039945_1_0_1; -.
DR InParanoid; G3X7E9; -.
DR OMA; YDICEKQ; -.
DR OrthoDB; 5305678at2759; -.
DR TreeFam; TF331549; -.
DR Reactome; R-BTA-6785807; Interleukin-4 and Interleukin-13 signaling.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000019338; Expressed in neutrophil and 102 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040566; Il13Ra_Ig.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR PANTHER; PTHR23037; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23037:SF28; ERYTHROPOIETIN RECEPTOR; 1.
DR Pfam; PF18001; Il13Ra_Ig; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..424
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018734159"
FT TRANSMEM 341..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..122
FT /note="Interleukin-13 receptor subunit alpha-1 Ig-like"
FT /evidence="ECO:0000259|Pfam:PF18001"
FT DOMAIN 128..221
FT /note="Type I cytokine receptor cytokine-binding"
FT /evidence="ECO:0000259|Pfam:PF09240"
SQ SEQUENCE 424 AA; 48214 MW; AEAE4E809AE773BF CRC64;
MERPARLCGL WVLLLYAGRG GVAAPAESQP PVTNLSVSVE NLCTIIWTWN PPEGASPNCS
LKYFSHFGNK QDKKIAPETH RSKEVPLNER ICLQVGSQCS TNESEKPSIL VEKCISPPEG
DPESAVTELQ CIWHNLRYMK CTWLPGRNAS PDTNYTLYYW HNSLGKILQC ENIYREGQHI
ACSFNLTKVK DSSFEQHSVQ VMVKDNAGKI RPSFNIVPLT SHVKPDPPHI KNLSFQNGDL
YVQWTNPQNF QSKCLSYEVE VNNSHAETHD IFYVEEAKCQ NTEFEGNLEG TICFMVPGVL
PDTLNTVRIR VKTNKLCYED DKLWSNWSQA MSIGQKANQT FYITTLLIIP VIVAAAVIVL
LLYLKRLKII IFPPIPDPGK IFKEMFGDQN DDTLHWKKYD IYEKQTKEET DSVVLIESLK
RASQ
//
