ID G3X7R5_BOVIN Unreviewed; 470 AA.
AC G3X7R5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=NOVA alternative splicing regulator 1 {ECO:0000313|Ensembl:ENSBTAP00000041566.4};
GN Name=NOVA1 {ECO:0000313|Ensembl:ENSBTAP00000041566.4,
GN ECO:0000313|VGNC:VGNC:84869};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000041566.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000041566.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000041566.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000041566.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000041566.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PTBP2; the interaction is direct.
CC {ECO:0000256|ARBA:ARBA00034798}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3X7R5; -.
DR Ensembl; ENSBTAT00000044049.4; ENSBTAP00000041566.4; ENSBTAG00000002170.6.
DR VEuPathDB; HostDB:ENSBTAG00000002170; -.
DR VGNC; VGNC:84869; NOVA1.
DR eggNOG; KOG2191; Eukaryota.
DR GeneTree; ENSGT00940000155573; -.
DR HOGENOM; CLU_022670_1_1_1; -.
DR TreeFam; TF316981; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000002170; Expressed in semen and 97 other cell types or tissues.
DR ExpressionAtlas; G3X7R5; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22435; KH-I_NOVA_rpt1; 1.
DR CDD; cd22436; KH-I_NOVA_rpt2; 1.
DR CDD; cd09031; KH-I_NOVA_rpt3; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 3.
DR InterPro; IPR047275; KH-I_NOVA_rpt1.
DR InterPro; IPR047276; KH-I_NOVA_rpt2.
DR InterPro; IPR047274; KH-I_NOVA_rpt3.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR10288:SF229; RNA-BINDING PROTEIN NOVA-1; 1.
DR Pfam; PF00013; KH_1; 3.
DR SMART; SM00322; KH; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR PROSITE; PS50084; KH_TYPE_1; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}.
FT DOMAIN 11..84
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 133..205
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 383..456
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 101..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 48037 MW; 2A14E9BAC48689A2 CRC64;
MHPMHRGRED GQYFLKVLIP SYAAGSIIGK GGQTIVQLQK ETGATIKLSK SKDFYPGTTE
RVCLIQGTVE ALNAVHGFIA EKIREMPQNV AKTEPVSILQ PQTTVNPDRI KQTLPSSPTT
TKSSPSDPMT TSRANQVKII VPNSTAGLII GKGGATVKAI MEQSGAWVQL SQKPDGINLQ
ERVVTVSGEP EQNRKAVELI IQKIQEDPQS GSCLNISYAN VTGPVANSNP TGSPYANTAE
VLPTAAAAAG LLGHANLAGV AAFPAVLSGF TGNDLVAITS ALNTLASYGY NLNTLGLGLS
QAAATGALAA AAASANPAAA AANLLATYAS EASASGSTAG GTAGTFALGS LAAATAATNG
YFGAASPLAA SAILGTEKST DGSKDVVEIA VPENLVGAIL GKGGKTLVEY QELTGARIQI
SKKGEFVPGT RNRKVTITGT PAATQAAQYL ITQRITYEQG VRAANPQKVG
//
