ID   G3X8J0_LOXAF            Unreviewed;       339 AA.
AC   G3X8J0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Fatty acid desaturase 6 {ECO:0000313|Ensembl:ENSLAFP00000017438.2};
GN   Name=FADS6 {ECO:0000313|Ensembl:ENSLAFP00000017438.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000017438.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000017438.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017438.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000017438.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000017438.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3X8J0; -.
DR   STRING; 9785.ENSLAFP00000017438; -.
DR   Ensembl; ENSLAFT00000022187.2; ENSLAFP00000017438.2; ENSLAFG00000021460.2.
DR   eggNOG; ENOG502QQ1J; Eukaryota.
DR   GeneTree; ENSGT00950000182990; -.
DR   HOGENOM; CLU_047135_0_0_1; -.
DR   InParanoid; G3X8J0; -.
DR   OMA; MFSRDKK; -.
DR   TreeFam; TF333083; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005804; FA_desaturase_dom.
DR   InterPro; IPR012171; Fatty_acid_desaturase.
DR   PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR   PANTHER; PTHR19353:SF13; FATTY ACID DESATURASE 6; 1.
DR   Pfam; PF00487; FA_desaturase; 1.
PE   4: Predicted;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          62..308
FT                   /note="Fatty acid desaturase"
FT                   /evidence="ECO:0000259|Pfam:PF00487"
SQ   SEQUENCE   339 AA;  38653 MW;  850F33606FC5893A CRC64;
     RRLCRHSRRG DESLQGELEA LVHDVVKASS WWERHGVDCA ILALSLLAVP AGLFCLRFEN
     VLVFALGITI LGVSHYTLTV KGSHLATHGA LTESKRWSKI WELFFLEVCT GFTAEYANYG
     HVKMRHGYTN VIGMGDSSTW RLPCLNRYVY MFLAPFLIPI ITPLVALKRL RDVEVWTALR
     TLGLISLGLY SHYWLLLNVS GFKSPRSALA CMFATRSLLA HPYLHVNIFQ HIGLPMFSLD
     KKPLRVHMLS LGVLNLPRSP VLDWAFGHSI VSCHVEHHFF PRLSDNMCLK VKPVVSHFLQ
     EKQLPYNEDS YLARFRLFLS CYEELMVHTP PITELVGLQ
//