ID G3X9H7_MOUSE Unreviewed; 759 AA.
AC G3X9H7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=MTSS I-BAR domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000079239.7};
GN Name=Mtss1 {ECO:0000313|Ensembl:ENSMUSP00000079239.7,
GN ECO:0000313|MGI:MGI:2384818};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000079239.7, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000079239.7, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079239.7,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000079239.7}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000079239.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_659049.2; NM_144800.2.
DR AlphaFoldDB; G3X9H7; -.
DR SMR; G3X9H7; -.
DR jPOST; G3X9H7; -.
DR MaxQB; G3X9H7; -.
DR PeptideAtlas; G3X9H7; -.
DR ProteomicsDB; 330646; -.
DR Antibodypedia; 27094; 251 antibodies from 29 providers.
DR DNASU; 211401; -.
DR Ensembl; ENSMUST00000080371.8; ENSMUSP00000079239.7; ENSMUSG00000022353.11.
DR GeneID; 211401; -.
DR KEGG; mmu:211401; -.
DR UCSC; uc007vtx.2; mouse.
DR AGR; MGI:2384818; -.
DR CTD; 9788; -.
DR MGI; MGI:2384818; Mtss1.
DR VEuPathDB; HostDB:ENSMUSG00000022353; -.
DR GeneTree; ENSGT00950000183156; -.
DR HOGENOM; CLU_004805_2_0_1; -.
DR OMA; AGAFPHC; -.
DR OrthoDB; 3875239at2759; -.
DR PhylomeDB; G3X9H7; -.
DR TreeFam; TF320619; -.
DR BioGRID-ORCS; 211401; 7 hits in 80 CRISPR screens.
DR ChiTaRS; Mtss1; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000022353; Expressed in cerebellum lobe and 257 other cell types or tissues.
DR ExpressionAtlas; G3X9H7; baseline and differential.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0003785; F:actin monomer binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0007009; P:plasma membrane organization; IEA:InterPro.
DR CDD; cd07643; I-BAR_IMD_MIM; 1.
DR CDD; cd22060; WH2_MTSS1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR013606; I-BAR_dom.
DR InterPro; IPR030127; MTSS1/MTSS2.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR15708; ACTIN BUNDLING/MISSING IN METASTASIS-RELATED; 1.
DR PANTHER; PTHR15708:SF10; PROTEIN MTSS 1; 1.
DR Pfam; PF08397; IMD; 1.
DR Pfam; PF02205; WH2; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51338; IMD; 1.
DR PROSITE; PS51082; WH2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:G3X9H7,
KW ECO:0007829|MaxQB:G3X9H7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..254
FT /note="IMD"
FT /evidence="ECO:0000259|PROSITE:PS51338"
FT DOMAIN 731..748
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 259..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..638
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 759 AA; 82422 MW; B84B648C59FA1961 CRC64;
MEAVIEKECS ALGGLFQTII SDMKGSYPVW EDFINKAGKL QSQLRTTVVA AAAFLDAFQK
VADMATNTRG GTREIGSALT RMCMRHRSIE AKLRQFSSAL IDCLINPLQE QMEEWKKVAN
QLDKDHAKEY KKARQEIKKK SSDTLKLQKK AKKVDAQGRG DIQPQLDSAL QDVNDKYLLL
EETEKQAVRK ALIEERGRFC TFISMLRPVI EEEISMLGEI THLQTISEDL KSLTMDPHKL
PSSSEQVILD LKGSDYSWSY QTPPSSPSTT MSRKSSVCSS LNSVNSSDSR SSGSHSHSPS
SHYRYRSSNL AQQAPVRLSS VSSHDSGFIS QDAFQSKSPS PMPPEAANQL SNGFSHCSLS
SESHAGPVGA GPFPHCLPAS RLLPRVTSVH LPDYAHYYTI GPGMFPSSQI PSWKDWAKPG
PYDQPLVNTL QRRKEKREPD SNGGGPTTTG GPPAGAEEAQ RPRSMTVSAA TRPGEEMAAC
EELTLALSRG LQLDVQRSSR DSLQCSSGYS TQTTTPCCSE DTIPSQVSDY DYFSVSGDQE
AEQQEFDKSS TIPRNSDISQ SYRRMFQAKR PASTAGLPTT LGPAMVTPGV ATIRRTPSTK
PSVRRGTIGA GPIPIKTPVI PVKTPTVPDL PGVLPSPPDG PEERGEHSPE SPSAGEGPQG
VSNIPSSLWS GQAPVNPPLP GPKPSIPEEH RQAIPESEAE DQERDPPSAT VSPGPIPESD
PADLSPRESP QGEDMLNAIR RGVKLKKTTT NDRSAPRFS
//
