ID G3XNH7_ASPNA Unreviewed; 829 AA.
AC G3XNH7;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 03-MAY-2023, entry version 40.
DE RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=ASPNIDRAFT_53870 {ECO:0000313|EMBL:EHA27921.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA27921.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA27921.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC biogenesis, stability and to maintain vacuole morphology.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA27921.1}.
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DR EMBL; ACJE01000002; EHA27921.1; -; Genomic_DNA.
DR AlphaFoldDB; G3XNH7; -.
DR STRING; 380704.G3XNH7; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_53870; -.
DR HOGENOM; CLU_008909_1_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF117289; Nucleoporin domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 7..409
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 503..811
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 829 AA; 93495 MW; 645FFC3000229BE4 CRC64;
MAPSNPLANW ERLGDSFYRK VPIYDAIFDD DVELENYIIA GAPYGGAIAL HRDESKPYRF
RDAQTAKSSI DIYSCSGKHI NRINWEYGTI RGLGWSDKEE LLVITEDGTV RRYFGLHGDF
TSFSLGNGAE DYGVRACRFW TSGFVALLSN NQLVAVSNYD EPRPRLLAPC PEGEVSSWSL
IPPAYTLSRS VEVLLAVDKT VYLVDPTEAE DKVLQNGPFK HASVSPTGRF VALITAEGKV
WVVSSDFQSK YSEYDPESRV TPRTVDWCGD DAVVIAWEDE VHLIGPNGVA ARYYYDGTVH
VVPEFDGVRL ITHDTCEFLH KVVDVTEAIF RLGSTSPASV LLDSIDLLEK KSPKADENIQ
RIRPSLPEAV DTCVKAAGHE FDTYWQKRLL KAASFGKSVL DLYNSDEFVE MTEKLRVLKA
VRDYQIGLPL SYEQYMRLTP ERLIERLVNR HEYLLAIRIS EYLELPADRI YVHWASQKVK
VSTVDDDAVC KLIVQRLEGK PGISFELIAQ TAYDEGRAHL ATQLLNHEPR AGKQVPLLLD
MEEDEIALDK AIESGDVDLV NYVLLHLKTK LPLASFFRTI NTRPMASALV ETTARGQDTE
LLKDLFYQDD RPIDGSNVLL SEALDATDLP RKTEKLQLAS RLLSDSKDPS VVLQQKLLNE
ASQLLKVQEA LDKDLADRSE FLGLSLNETI YRLIRSGYGK RAQKIQSEFR MPEKTFWWLR
LRALVAKRDW GELEEIGKNK KSPIGWEPFY NEILGAGNTK LASLFVPKCT NLPAEDKMEM
WVKCGMIAKA GEEAFRAKNV NALELLQARA SGPAAVEIER MINQLRPRK
//
