ID G3XPN3_ASPNA Unreviewed; 1935 AA.
AC G3XPN3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
DE Flags: Fragment;
GN ORFNames=ASPNIDRAFT_138621 {ECO:0000313|EMBL:EHA27232.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA27232.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA27232.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA27232.1}.
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DR EMBL; ACJE01000003; EHA27232.1; -; Genomic_DNA.
DR STRING; 380704.G3XPN3; -.
DR HOGENOM; CLU_000893_1_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 2.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1364..1550
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1623..1919
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 468..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHA27232.1"
FT NON_TER 1935
FT /evidence="ECO:0000313|EMBL:EHA27232.1"
SQ SEQUENCE 1935 AA; 214353 MW; D04585C51DB6A6F8 CRC64;
IRASALNRLA ALAVKGPECG SDSDIARLAQ QSLCPAHSSN DTLNGILQAQ APTSRVPMGM
RELDVLVALC KASPSVTNIE HASRLVSLLS QYLPEAHSQL FRPSPFLHNV KPSPWESLTH
NLTLALLSLG SSYSSLRSIV AGAFNEYLSN CAEAIKAVAP LHHYQAEANS RDAEQESTSV
LSISASLVGF LGASAALSSF WAPSEKLHLA NNLRSMLCER FLVAVETASS IVRNGSMSGY
LLREWRKYTR RYDSDGRPLG AMLLQEGFIR FLKSCVTRAA DMNGTSGAEL SHDHLLNLST
SKSSDDTEIA LTDRVAAIIA DEIQLLEDGS DYLRLGSPWK QRLAFSMKAL ALVGYLNCII
LCEDTTNKED FVSWLEDTLM DPNQMAYAEL ATAVLKSMAV ISRTSITIAS SGSRSLLRFI
VEGGAPTGTT GSIAGECLAH ILGGLSQDSV ITTLYSLGNV LSSGSGTDKS YQSHMPGDNS
AHGNTPLPIP TTRTGSVFSF SAEDEANNLS YKNVVRAIVQ IAVSCNDEKI SALAQSMLLQ
KIGKVNATID AFIITETAAI SLSTGQAEFQ LLLKFYDRAY RDGVARGYNS VTDAVKSALA
YLSITLKRDS PLYGVYLVHL LENVVNKGDA TDLESERQKE LALAADEISP LLRPLALLVS
SDKEQQDNAD TITDYDQDVS ALFRDAWFNI AVHGISMHSA VGQSQFEELR LLAKHSPPLV
SEDRMEATES DVELNTILRR GMGSQRFQEQ KRNLLAELPG HEAETKRLSY PQVVFLNATI
LVEKFRALSG KCTGFLDYFR DPAIATTEMA SCMSAIAEKV VASYLSLTMS GKSEGFSVAY
LSRELAGFFI ACSHRVERVQ NVAVLCANKI INECPSALCE KHSLFALLEL LTVMWRSCLE
GELDEFEWNP SFTSPTGLVK ADLPDNYNFR KKTLDVLLER SKTWVAAAMD IAPLDVKGLL
QTYLSLSDDH AGYGNILLGR SFALEMGSLI PSSDQRLGSM DSHGLSKINV ASDFISQYST
RQNYRTLYAQ SVSGPRQGTS GLSHNMLSGS FLSANTVMED TLYQLYARLK SGEVVPTVAV
RDALRQAAGL LCSDNDPSAF LAQFLVQIPF EIFSKESMDI GISLWLGVMH ENPRVESKIL
VEVIGSWEKS IQRRKGLFDL NCNYVDPMFS KIELLPSDKA LMAKNQQKSQ GILTPHFQLL
QFFESHFAAV RLANFQVKSL FGRLVDKTSV GLLHASGHPL ARELHFRIVL FGLRVLKDSR
LPDRNLEWKL KDQILSAALT WFRHPPRWSF GGNRLQIKAE DRILGDVSSA LADVAGVTGH
SRSSSRTLQA RQELLQILLE DERSRLRVWL YPLEPDRKHN MAQSAAVRTF TEDATNLLRL
AWSEAPGLAI HLSTRFPSLK LKNDIRWLVL NFPDKAIDEP SALEVIFGSA LPADVHSQLK
FLLYWAPVNP AEALTYFLPT YGNHPFILQY AMKALESHSV DVRFYFVPQL VQALRYDALG
YVERYIMETA KLSQLFAHQV IWNMKANSYK DEDSQIPDPL KPTLDKFMDA LISSFTDEER
EFYEKEFSFF NEITGISGKL RPYIKRSKAE KKEKIEEELR KIKVEVGVYL PSNPDGVVVG
IDRKSGKPLQ SHAKAPYMAT FRIQKTRARS DDDKITQKAG DGRSSNGVQE TYEVWQSAIF
KVGDDCRQDM LALQMIAAFR GIFASVGLDV WVFPYRVTST APGCGVIDVL PNSISRDMLG
REAKYGGEES IRFQEARTNF VKSMAAYSVI SYLLQFKDRH NGNIMVDDAG HIIHIDFGFC
FDIAPGGVRF ERAPFKLTSE MVAVMSGSGL GLPGGGSHSP TSTQPYKWFE SLVVKAFLAS
RPYSSKLSHI VSLMLDSGLP CFKPDTLKNF RDRFVLDKTE REAAEYMREL VRKSYMSVST
KGYDQFQLLT NGIPY
//
