ID G3XY66_ASPNA Unreviewed; 758 AA.
AC G3XY66;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
DE Flags: Fragment;
GN ORFNames=ASPNIDRAFT_129697 {ECO:0000313|EMBL:EHA24696.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA24696.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA24696.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA24696.1}.
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DR EMBL; ACJE01000008; EHA24696.1; -; Genomic_DNA.
DR AlphaFoldDB; G3XY66; -.
DR STRING; 380704.G3XY66; -.
DR HOGENOM; CLU_005126_10_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF0; K(+)_H(+) ANTIPORTER 1; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..431
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 508..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHA24696.1"
FT NON_TER 758
FT /evidence="ECO:0000313|EMBL:EHA24696.1"
SQ SEQUENCE 758 AA; 82165 MW; CD9D30BE5B50BFFB CRC64;
LRADTMSSNS TTKVKAQGGI LEGSNPAHYD SSNPIVIFII QAGIIIIFCR LLHWPLSKIR
QPRVIAEVIA GVILGPSVMG RIPGFTDAIF PTASIPNLNL VANLGLVLFL FLVGLETNLR
FLVSNWRVAV SVSAAGMILP FGLGCAIAYG LYNTFQDEPD TVDINFGTFL LFIGIAMAIT
AFPVLCRILT ELKLLGTNVG VIVLSAGVGN DVVGWILLAL CVALVNAGTG LTALWVLLVC
VGYILFLTFI FRPLFLRFLR HTGSLQKGPS QSVVAITLLI ALASAFFTQI IGIHAIFGGF
IIGLLCPHEG GFAIKLTEKI EDLVAALFLP LYFTLSGLQT NLGLLDNGTV WGYVVGIIAI
AFTAKVAGGA LASRLCGLLW RESFSIGVLM SCKGLVELIV LNIGLQARIL STRTFTMFVV
MALVTTFATT PLTVALYPKW YQVKVERWRR GEIDWKTGNP IPSDARTDSI ALAKEQHRAL
PVRKLLVYLR LDGLSSICTL AALLSPNRPP LPKQHPDTLA SPDPAAEETA TATTKTEEDE
DQEDQDPKPT LQVHGVRLLE LTDRDSSVMT VSELDQLHYP VWDPVVNTFR AFGQWHDLSI
VAGVSVVPEH SYADTVVSMA RDDSTDLLLL PWSETGSMSE HHPLDLNSVL DDPNATRFVA
SAPYTAFAES VLRNVRCNVG LLVERTPTRR NNGRGLRGKP SLGGLSIHSG NLNMGIGSSG
DRGVAVVPTT RKAHHILLPY FGGKDDRFAI RLVLQLIR
//
