ID G3Y0K8_ASPNA Unreviewed; 946 AA.
AC G3Y0K8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE RecName: Full=ER membrane protein complex subunit 1 {ECO:0000256|ARBA:ARBA00020824};
GN ORFNames=ASPNIDRAFT_56222 {ECO:0000313|EMBL:EHA23919.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA23919.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA23919.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000256|ARBA:ARBA00011276}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the EMC1 family.
CC {ECO:0000256|ARBA:ARBA00007904}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA23919.1}.
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DR EMBL; ACJE01000009; EHA23919.1; -; Genomic_DNA.
DR AlphaFoldDB; G3Y0K8; -.
DR STRING; 380704.G3Y0K8; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1104971; -.
DR HOGENOM; CLU_005034_0_1_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0072546; C:EMC complex; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR026895; EMC1.
DR InterPro; IPR011678; EMC1_C.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR21573:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR21573; UNCHARACTERIZED; 1.
DR Pfam; PF07774; EMC1_C; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 2.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..946
FT /note="ER membrane protein complex subunit 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003460612"
FT TRANSMEM 914..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 724..943
FT /note="ER membrane protein complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07774"
SQ SEQUENCE 946 AA; 102851 MW; 8917F26300EDA1E7 CRC64;
MWLQATLLLL ASCVPSSLAI YRDEVNHVDY HHALLGFPTS QSTFFLKPST TSNASLLYTL
SEKSLLGAVN PRDGSLVWRQ NLSRSDLPAA ESNPHGLLRA SEGTNALVSA LGDYISSWTA
LDGKLIWENW FEGEVVADLE LLELEDASAA PSTKDTLALW SGKAGVVRRL DGDSGRTKWE
HLDESGDIPL QLSSSATEVF YVALQPSSRK GYRIKVTSLD PLTGRQTRQQ ILSSESDLSS
TNSVLFVGAN TAAPMIVWAD QSFKTLKVNV IGTKQVHSFD IENTSGESVS SITVHAPKKL
ESLPHFLVHY ETESTTWAEV YHVDLKSASV SKAYELPRLQ GWSVFSTSNK DANVYFTRIT
QSETTVVSSA SHGVLGRWVH QAPPMEQALH SVSEVVAKDK SVAVRTAAAL ESGDWQLIRN
GQTEWTRYEA LSGALAATWV EEAVQEDLAH QLEVEGHESL YGAYVHRVKR HVRDLQHLPE
WLKGLPKRIL TSILTDEVSN LDSFGIVKSV IVATENGRVY ALDAAKHGAV SWKVKAAEAD
SWNVKAILAH PGTATVYVDD GSSVTLDATS GEILARTPGT AKIRSVAVAH DGNAPVTVGI
KDNGTPLAPI DGPGFFVTLS DDGRVLGWAA RDNKHPVWQF LPTPGEKIIQ ATARPSHDPV
ASIGKVLGNR SVLYKYLNPN LALITAVGES SATFYLLDAI SGKILHSSTH QGVDPTQPIA
SVISENWFAY SFWADAVDPS SAKGYQLVIS ELYESPVPND RGPLDSASNY SSISDLPLPH
VISQAFIIPE PISHMAVTQT RQGITVRQLL CTLPSSNAII GIPRPVLDPR RPIGRDPTST
EAEEGLFKYN PFLEFDGKWY HTHSREVSGI KSVLSAPTLL ESTSLIFAFG GDIFATRATP
SQAFDVLGKG FSKLQLVLTI VALTAGVIVL APMVKRKQIN MIWKSR
//
