ID G3Y2I4_ASPNA Unreviewed; 810 AA.
AC G3Y2I4;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EHA22804.1};
DE Flags: Fragment;
GN ORFNames=ASPNIDRAFT_173212 {ECO:0000313|EMBL:EHA22804.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA22804.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA22804.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA22804.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACJE01000010; EHA22804.1; -; Genomic_DNA.
DR AlphaFoldDB; G3Y2I4; -.
DR STRING; 380704.G3Y2I4; -.
DR HOGENOM; CLU_348388_0_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF3; 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600); 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
FT DOMAIN 510..670
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 679..798
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT NON_TER 810
FT /evidence="ECO:0000313|EMBL:EHA22804.1"
SQ SEQUENCE 810 AA; 89145 MW; AB04CA77A9FDD31B CRC64;
MSYTYRYGSA DNSSSRSSST PCILFLTNSE REHSGVTLAV VHEFLIGNSP YKVHIGSFGP
LKRHIAELNY YAAASGSPCA TEAVFEEIPG MSMKHVRMRD GQFDDIPQVG FFAALKNYRK
DLALGLLPWT GDDYVEIFDA VVELVKTLGP VLIVVDPLFA PAVDVCRYLR WRHYPMICSG
FKMPMSLWDK LRNIFLGFRF KHELEKCASL KGVNDAREAR GIEGPVPFLS HEAKKSSRII
LPSWPETDFP LVVPEHMTLC GPILRRYRPM VKEDPELAHW LSKRPTVLVL MDSRFSYDGK
QQIEIAKAIQ KLLEQELNMQ VLWKLKHVED PAVTREIVKL LGVYIHGKRM RIAKRFVFEI
MSLLMSGHVT CLVHHGGANV FHEAVRAEIP QIVLPVWFDA YDYAARVEYL GIGIWGSRRS
APKVSGEELG DALLRVVTAS DESHAMRMRA MQVAGQLPFK DGRVVAYERL LELLPPSFNY
YSPNKSYNPS NPSNSSLLIT ITTTTMANER ITWIGLGNIG RAMAANIAQK GPQTTPVTLY
NRTTSKATDF ASTLPANKAT VSTSLSDAIS NSTIIFICVG DDAALEAIIS GLPTASLSSK
IIVDCSTVHP DTSRKIQRQL ASHGASFIAC PVFGAPAAAI AGQLVVVPAG DAATIDRIKP
FLDGVTSKAT ISMAGEDVGR ATTLKILGNT FILNTVETVA EGLVTAEKTG LGADVYQQFL
HTFFPGPFAL YADRMVTGDY HTREEPLFAV DLARKDLRHA SSLAGEAGVR LRSVEVTDHH
LQTVKAEKGE KGDIAAVYGS VRKESGLPFE
//
