ID G3Y2Q8_ASPNA Unreviewed; 730 AA.
AC G3Y2Q8;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 22-FEB-2023, entry version 41.
DE RecName: Full=RNA exonuclease 4 {ECO:0000256|ARBA:ARBA00016937};
DE AltName: Full=Ribosome biogenesis protein NOP53 {ECO:0000256|ARBA:ARBA00018339};
DE Flags: Fragment;
GN ORFNames=ASPNIDRAFT_197959 {ECO:0000313|EMBL:EHA23571.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA23571.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA23571.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- FUNCTION: Exoribonuclease involved in ribosome biosynthesis. Involved
CC in the processing of ITS1, the internal transcribed spacer localized
CC between the 18S and 5.8S rRNAs. {ECO:0000256|ARBA:ARBA00025599}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the NOP53 family.
CC {ECO:0000256|ARBA:ARBA00008838}.
CC -!- SIMILARITY: Belongs to the REXO4 family.
CC {ECO:0000256|ARBA:ARBA00010489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA23571.1}.
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DR EMBL; ACJE01000010; EHA23571.1; -; Genomic_DNA.
DR AlphaFoldDB; G3Y2Q8; -.
DR STRING; 380704.G3Y2Q8; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1122894; -.
DR HOGENOM; CLU_022816_0_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR CDD; cd06144; REX4_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR InterPro; IPR011687; Nop53/GLTSCR2.
DR InterPro; IPR037431; REX4_DEDDh_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR14211; GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2; 1.
DR PANTHER; PTHR14211:SF7; RIBOSOME BIOGENESIS PROTEIN NOP53; 1.
DR Pfam; PF07767; Nop53; 1.
DR Pfam; PF00929; RNase_T; 1.
DR SMART; SM00479; EXOIII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 534..696
FT /note="Exonuclease"
FT /evidence="ECO:0000259|SMART:SM00479"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 730
FT /evidence="ECO:0000313|EMBL:EHA23571.1"
SQ SEQUENCE 730 AA; 83402 MW; 45CD735AB2F1F0F3 CRC64;
MSEAISAPKQ YKQPSRKGKK AWRKNVDIDE VQEGLRVLKE EEIKGGLLSE KPSDELFVID
TKGSSEIRDA YRKKHKPLKS EEILAQRSAI PGLDTRKRTN SKVTDGVIEP KNKRQKSDWV
TRKDWLRLKQ VAKEGNPVNK PAENDLYDPW GDAEEPTPLD DPQFDFLEKP KPKVEPVTLK
QAPISLAANG KPVPAVRKPT AGISYNPTFE DWDRLLQEQG EKAVEAEKKR LEEERKEEER
QRLIAEAQDD DGMVKSDDES AWEGFESEYE KPDWLNKKRP ERKTKAQRNK IKRRKEAERQ
AKWEEQMKRK EEQAAYAKEA AERVEAQALA RADDSEDSSS EEGDDTVLRR KPLGGKLYAP
EKPLEVVLPD ELQDSLRLLK PEGNLLDDRF RTLVVQGKLE SRKPVTQAKK PKRKVTEKWS
HKDFKIPGLN WKKLQGTLKK ESVSATKRKP SDRETENGVV KKRKRETVDG QQKPERKPVS
TKRKKMSTNG TDGGENGTEE PTKKSISRRN STAAVAESKP KINEGRSPTA ELGKYVAMDC
EMVGVGPNPD HDSALARVSI VNFNGEQIYD SYVRPKEMVT DWRTHVSGIL PKHMVEARTL
EQVQKDVINI LDGRILVGHA VSNDLDALLL SHPKRDIRDT SKHPPYRKIA GGGSPRLKML
ASEFLGLEIQ DGAHSSVEDA RATMLLYRRD KDTFEREHLK KWPVRVVVEK KDQDDDQKKK
KKKKKKTRKR
//
