ID G3Y435_ASPNA Unreviewed; 786 AA.
AC G3Y435;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 13-SEP-2023, entry version 44.
DE RecName: Full=Aldolase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ASPNIDRAFT_213851 {ECO:0000313|EMBL:EHA22212.1};
OS Aspergillus niger (strain ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 /
OS NCTC 3858a / NRRL 328 / USDA 3528.7).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=380704 {ECO:0000313|EMBL:EHA22212.1, ECO:0000313|Proteomes:UP000009038};
RN [1] {ECO:0000313|EMBL:EHA22212.1, ECO:0000313|Proteomes:UP000009038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1015 / CBS 113.46 / FGSC A1144 / LSHB Ac4 / NCTC 3858a /
RC NRRL 328 / USDA 3528.7 {ECO:0000313|Proteomes:UP000009038};
RX PubMed=21543515; DOI=10.1101/gr.112169.110;
RA Andersen M.R., Salazar M.P., Schaap P.J., van de Vondervoort P.J.,
RA Culley D., Thykaer J., Frisvad J.C., Nielsen K.F., Albang R., Albermann K.,
RA Berka R.M., Braus G.H., Braus-Stromeyer S.A., Corrochano L.M., Dai Z.,
RA van Dijck P.W., Hofmann G., Lasure L.L., Magnuson J.K., Menke H.,
RA Meijer M., Meijer S.L., Nielsen J.B., Nielsen M.L., van Ooyen A.J.,
RA Pel H.J., Poulsen L., Samson R.A., Stam H., Tsang A., van den Brink J.M.,
RA Atkins A., Aerts A., Shapiro H., Pangilinan J., Salamov A., Lou Y.,
RA Lindquist E., Lucas S., Grimwood J., Grigoriev I.V., Kubicek C.P.,
RA Martinez D., van Peij N.N., Roubos J.A., Nielsen J., Baker S.E.;
RT "Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015
RT versus enzyme-producing CBS 513.88.";
RL Genome Res. 21:885-897(2011).
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC {ECO:0000256|ARBA:ARBA00008131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHA22212.1}.
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DR EMBL; ACJE01000012; EHA22212.1; -; Genomic_DNA.
DR AlphaFoldDB; G3Y435; -.
DR STRING; 380704.G3Y435; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1123188; -.
DR HOGENOM; CLU_019743_0_0_1; -.
DR Proteomes; UP000009038; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR CDD; cd00408; DHDPS-like; 1.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF00701; DHDPS; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 36..227
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 268..402
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 84771 MW; 14F6D25BFECA65EB CRC64;
MLVTDTSIKP TSDEATAQSP TTPSSPTHSN SRYSTHIVLT TYPGQSGIDP IPLEWGAPDA
KSRGPVVVSR SSALLKRRNA MGAHGGSYSI YNALAIAAGD LEPNFRPDLS NSQPTFNFPW
QPAWADKTKI VSMDPWGHDI VNQFRDELSK GWDIRPTMAV TRANMNFAEI AEAVKEGKLE
VDGSIVVDSS GEVRVTKVAV EPVWYLPGVA ERFGVDEGTL RRTLFEHTGG SYPELITRPD
LKVFLPPIGG LTVYIFGPPE RVSDENVKLA LRIHDECNGS DVFQSDICTC RPYLAFGIRE
AIREAQSGGS GVVIYFRKEG RALGEVIKYL VYNARKRGGD TADKYFTRTE NIAGVRDMRF
QALMPDILHW LGIKKIDRML SMSNMKHDAI VESGIKILER IPIPDEMIPT DSRVEIDAKI
NAGYFTTGKN VTAEDLAAVR GRGWEKWEDI TVYLTITMGS SVAVTPQPHI PKAGVWCPAV
TFFDHSTDTI DLDAQKKYYQ YLSTTGLAGL VILGTNSEAF LLTREERAQL IATARAAVGP
DYPLMAGCGA HSTKQVLELA EDAAAAGANY ILVLPPAYFG KATTPAVVKR FFADVARKSP
LPVVVYNFPG VCNGVDLDSE TITAIVRESA ASSTNGVSNV VGVKLTCGSV GKITRLAATF
SKEEFAIYGG QSDFLIGGLA AGSAGCIAAF ANVFPKTASK IYDLYVAGKI QEAVELQRQA
ALAESPCKSG IAATKYAAAI FSARAAGIEG AEEKLKPRTP YEEPAEGAKK GVQDLMSAVA
KVEGSI
//
