ID   G4CJ85_9NEIS            Unreviewed;       258 AA.
AC   G4CJ85;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=Pyruvate dehydrogenase complex repressor {ECO:0000256|ARBA:ARBA00039592};
GN   Name=pdhR {ECO:0000313|EMBL:EGY52179.1};
GN   ORFNames=HMPREF9371_1674 {ECO:0000313|EMBL:EGY52179.1};
OS   Neisseria shayeganii 871.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=1032488 {ECO:0000313|EMBL:EGY52179.1, ECO:0000313|Proteomes:UP000003019};
RN   [1] {ECO:0000313|EMBL:EGY52179.1, ECO:0000313|Proteomes:UP000003019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=871 {ECO:0000313|EMBL:EGY52179.1,
RC   ECO:0000313|Proteomes:UP000003019};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC       complex genes aceEF and lpd. {ECO:0000256|ARBA:ARBA00037357}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGY52179.1}.
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DR   EMBL; AGAY01000059; EGY52179.1; -; Genomic_DNA.
DR   RefSeq; WP_009119364.1; NZ_JH164926.1.
DR   AlphaFoldDB; G4CJ85; -.
DR   STRING; 1032488.HMPREF9371_1674; -.
DR   PATRIC; fig|1032488.3.peg.1584; -.
DR   HOGENOM; CLU_017584_9_5_4; -.
DR   OrthoDB; 5296437at2; -.
DR   Proteomes; UP000003019; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.20.120.530; GntR ligand-binding domain-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43537:SF34; PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR; 1.
DR   PANTHER; PTHR43537; TRANSCRIPTIONAL REGULATOR, GNTR FAMILY; 1.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF48008; GntR ligand-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Pyruvate {ECO:0000313|EMBL:EGY52179.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003019};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          10..78
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50949"
SQ   SEQUENCE   258 AA;  29061 MW;  45F9E2AEF9C330B6 CRC64;
     MSQNTIVKAQ KLSEQISSAL EERILSGIYP VGSRLPAERL LAEEFGVSRP PVRDALRTLA
     TRGLTFSKPG GGHYVSEDLH TDFLSSWQSL IQRHDYLRQD VLDFRRHIEG TLAALAAERR
     TETDLARLQY WLLELEAAYE RQDLVRQAEA DVAFHQAIAD AAHNTLFSHL AASLLLMIHR
     HTQSNLANMF SYTSAKEDLH GQHRAIFHAI ASGEPDAAAA VARRHIDFVA DTLQAAQEHI
     EREQISAALA EKDRKRRR
//