ID G4CKN5_9NEIS Unreviewed; 272 AA.
AC G4CKN5;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=tRNA pseudouridine synthase C {ECO:0000256|ARBA:ARBA00040675};
DE EC=5.4.99.26 {ECO:0000256|ARBA:ARBA00038943};
DE AltName: Full=tRNA pseudouridine(65) synthase {ECO:0000256|ARBA:ARBA00041975};
DE AltName: Full=tRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00043049};
DE AltName: Full=tRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00041803};
GN Name=truC {ECO:0000313|EMBL:EGY51568.1};
GN ORFNames=HMPREF9371_2175 {ECO:0000313|EMBL:EGY51568.1};
OS Neisseria shayeganii 871.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1032488 {ECO:0000313|EMBL:EGY51568.1, ECO:0000313|Proteomes:UP000003019};
RN [1] {ECO:0000313|EMBL:EGY51568.1, ECO:0000313|Proteomes:UP000003019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=871 {ECO:0000313|EMBL:EGY51568.1,
RC ECO:0000313|Proteomes:UP000003019};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000256|ARBA:ARBA00037670}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC Evidence={ECO:0000256|ARBA:ARBA00036607};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGY51568.1}.
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DR EMBL; AGAY01000074; EGY51568.1; -; Genomic_DNA.
DR AlphaFoldDB; G4CKN5; -.
DR STRING; 1032488.HMPREF9371_2175; -.
DR PATRIC; fig|1032488.3.peg.2055; -.
DR HOGENOM; CLU_016902_11_4_4; -.
DR Proteomes; UP000003019; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF56; TRNA PSEUDOURIDINE SYNTHASE C; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:EGY51568.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003019};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 36..195
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
SQ SEQUENCE 272 AA; 30861 MW; 6FD4D134AB5A3F68 CRC64;
MRVLQRSQPV CLEGLFGFQV ARMCMIPILY QDEACLAVCK PAGMLIHRSA IDRRETVFLM
QTLRDQIGGH VYPVHRLDRP TSGVVLFARD PEAARLLTRQ FENREVDKEY WAVVRGWPPE
CGRIDHPLKT LADPLADPLA DPDKAAQQAI SDYRTLARAE LPFASHPRHP TSRYAWLAVS
PLTGRQHQIR RHLKHIFHPI VGDTTHGDLR QNHAVAAFCG NRRLLLHARA LSFCSPQKPG
CRITAQAEPD TAWRQVMRAF GWPEVLHAEQ AT
//
