ID G4CRS3_9NEIS Unreviewed; 751 AA.
AC G4CRS3;
DT 14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2011, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Competence factor transporting permease/ATP-binding protein ComA {ECO:0000313|EMBL:EGZ45224.1};
GN Name=comA {ECO:0000313|EMBL:EGZ45224.1};
GN ORFNames=HMPREF9370_1783 {ECO:0000313|EMBL:EGZ45224.1};
OS Neisseria wadsworthii 9715.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=1030841 {ECO:0000313|EMBL:EGZ45224.1, ECO:0000313|Proteomes:UP000005336};
RN [1] {ECO:0000313|EMBL:EGZ45224.1, ECO:0000313|Proteomes:UP000005336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9715 {ECO:0000313|EMBL:EGZ45224.1,
RC ECO:0000313|Proteomes:UP000005336};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGZ45224.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AGAZ01000061; EGZ45224.1; -; Genomic_DNA.
DR AlphaFoldDB; G4CRS3; -.
DR STRING; 1030841.HMPREF9370_1783; -.
DR PATRIC; fig|1030841.3.peg.1773; -.
DR HOGENOM; CLU_010363_3_0_4; -.
DR Proteomes; UP000005336; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EGZ45224.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000313|EMBL:EGZ45224.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 502..681
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 751 AA; 81765 MW; 312EBF1FBA30C6B3 CRC64;
MRFFERCLPA WVVGITASFA LPAVPAWYVA AMAGLGLLLA ARRSGVAAVL LVALLGAVYG
TWRTELVLAN QWPVAQVEAN MLTLKVTGLP QREERWVRFE AQVQDFSGRQ WRVQLSDYSL
RDWPIGSVWR AKVRVRAPVG EVNLRGFNRE AWALANGLSG TGTVGKERER IGQGQEIGLQ
QLRAAVSGNW QQVQGFEQGV ALMRALSIGE QSALPNRAWQ AFRPLGLTHL VSISGLHVSM
VGLLAALLAR MVLRRLPFSF KRPRTVMLLV GLSAAFAYAL LAGFGVPTQR TVLMLAAFAW
IWHSRKGQSV WFAWWAALAA VLLFDPLAVL GVGTWLSFGL VAALLWVSAW RLEEKGQVVF
WRGQYALLLV SLVALGFMFA ALPLISSLVN LIAVPWFSWV LVPLALAASA FPVEPLQMLA
AGAGEYTMRA LFWLGSWAPE WSMAAAPVSL LWLAVAAVLV ALLPRGLGLK PWAFVVLAGF
TFYRPPAVPK QALKIMVWDV GQGLAVSFHT ASKTLLFDTG TEAAAQTQLI PSLRAMGVHK
LDGAVFSHHD NDHDGGAMLI RQAFSPATLW AGQPEFYPNA LSCHEAEAWD WDGVHFEFLS
LSEKAGDDNE QSCVLRVVAA EKALLVTGDL SQRGEQALIS RYGSGLYSQV LILGHHGSSS
ASSGAFLNAV APQYAIASSG FANAYGHPAK AVKTRLRAHG IQLLRTDLQG ARLVGFEPEE
ALSLGAERHE NKAYWQKKPF GKEAGQNESM P
//
