ID   G4CSK5_9NEIS            Unreviewed;       178 AA.
AC   G4CSK5;
DT   14-DEC-2011, integrated into UniProtKB/TrEMBL.
DT   14-DEC-2011, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase {ECO:0000313|EMBL:EGZ44651.1};
DE            EC=2.7.7.60 {ECO:0000313|EMBL:EGZ44651.1};
GN   Name=ispD {ECO:0000313|EMBL:EGZ44651.1};
GN   ORFNames=HMPREF9370_2065 {ECO:0000313|EMBL:EGZ44651.1};
OS   Neisseria wadsworthii 9715.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=1030841 {ECO:0000313|EMBL:EGZ44651.1, ECO:0000313|Proteomes:UP000005336};
RN   [1] {ECO:0000313|EMBL:EGZ44651.1, ECO:0000313|Proteomes:UP000005336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9715 {ECO:0000313|EMBL:EGZ44651.1,
RC   ECO:0000313|Proteomes:UP000005336};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-
CC       erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
CC       {ECO:0000256|ARBA:ARBA00002459}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGZ44651.1}.
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DR   EMBL; AGAZ01000069; EGZ44651.1; -; Genomic_DNA.
DR   AlphaFoldDB; G4CSK5; -.
DR   STRING; 1030841.HMPREF9370_2065; -.
DR   PATRIC; fig|1030841.3.peg.2057; -.
DR   HOGENOM; CLU_061281_3_0_4; -.
DR   Proteomes; UP000005336; Unassembled WGS sequence.
DR   GO; GO:0050518; F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR   InterPro; IPR034683; IspD/TarI.
DR   InterPro; IPR018294; ISPD_synthase_CS.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR32125; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR32125:SF4; 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   Pfam; PF01128; IspD; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS01295; ISPD; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:EGZ44651.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EGZ44651.1}.
SQ   SEQUENCE   178 AA;  19065 MW;  F233CC6901BAF6A5 CRC64;
     MAVVLSPEDN VFQTGIHEKL HVLKVGGQTR AESVRNGLSD LLKSGLAEET DNILVHDAAR
     CCLPQAALLR LIETAGACEE GGILAVPVAD TLKRAADNAI DATVPRRGLW QAQTPQLFRA
     GLLHKALAVP DLSAVTDEAS AVEMLGVHPL LVLGDTRNLK LTLPQDEYIV RLLLQQAD
//